ID 1.3.1.107 DE sanguinarine reductase. CA (1) dihydrosanguinarine + NADP(+) = NADPH + sanguinarine. CA (2) dihydrosanguinarine + NAD(+) = NADH + sanguinarine. CA (3) dihydrochelirubine + NAD(+) = chelirubine + NADH. CA (4) dihydrochelirubine + NADP(+) = chelirubine + NADPH. CC -!- The enzyme, purified from the California poppy (Eschscholzia CC californica), is involved in detoxifying the phytoalexin sanguinarine CC produced by poppy itself (cf. EC 1.5.3.12), when it binds to the cell CC wall of the poppy cell. CC -!- The reaction with NADPH is up to three times faster than that with CC NADH at low concentrations (<10 uM) of the dinucleotide. CC -!- At higher concentrations the reaction with NADPH is inhibited but not CC that with NADH. DR D5JWB3, SARED_ESCCA; //