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ENZYME entry: EC 1.3.1.110

Accepted Name
Lactate dehydrogenase (NAD(+),ferredoxin).
Alternative Name(s)
Electron bifurcating LDH/Etf complex.
Reaction catalysed
Lactate + 2 NAD(+) + 2 reduced ferredoxin [iron-sulfur] cluster <=> pyruvate + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
Comment(s)
The enzyme, isolated from the bacterium Acetobacterium woodii, uses flavin-based electron confurcation to drive endergonic lactate oxidation with NAD(+) as oxidant at the expense of simultaneous exergonic electron flow from reduced ferredoxin to NAD(+).
Cross-references
BRENDA1.3.1.110
EC2PDB1.3.1.110
ExplorEnz1.3.1.110
PRIAM enzyme-specific profiles1.3.1.110
KEGG Ligand Database for Enzyme Nomenclature1.3.1.110
IUBMB Enzyme Nomenclature1.3.1.110
IntEnz1.3.1.110
MEDLINEFind literature relating to 1.3.1.110
MetaCyc1.3.1.110
Rhea expert-curated reactions1.3.1.110
UniProtKB/Swiss-Prot
H6LBB0, LCTB_ACEWD;  H6LBB1, LCTC_ACEWD;  H6LBS1, LCTD_ACEWD;  

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