ID   1.3.1.114
DE   3-dehydro-bile acid Delta(4,6)-reductase.
CA   (1) 3-oxocholan-24-oyl-CoA + NAD(+) = 3-oxochol-4-en-24-oyl-CoA + H(+) +
CA   NADH.
CA   (2) 3-oxochol-4-en-24-oyl-CoA + NAD(+) = 3-oxochol-4,6-dien-24-oyl-CoA +
CA   H(+) + NADH.
CA   (3) 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-3-
CA   oxochol-4-en-24-oyl-CoA + H(+) + NADH.
CA   (4) 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD(+) = 12alpha-hydroxy-
CA   3-oxochola-4,6-dien-24-oyl-CoA + H(+) + NADH.
CC   -!- The enzyme, characterized from the bacterium Clostridium scindens,
CC       participates in the bile acid 7alpha-dehydroxylation pathway.
CC   -!- The enzyme catalyzes two subsequent reductions of the double bonds
CC       within the bile acid A/B rings, following 7alpha-dehydration.
DR   B0NAQ4, BAIN_CLOS5 ;
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