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ENZYME entry: EC 1.3.1.118

Accepted Name
Meromycolic acid enoyl-[acyl-carrier-protein] reductase.
Reaction catalysed
A meromycolyl-[acyl-carrier protein] + NAD(+) <=> a trans-Delta(2)-meromycolyl-[acyl-carrier protein] + NADH
Comment(s)
  • InhA is a component of the fatty acid synthase (FAS) II system of Mycobacterium tuberculosis, catalyzing an enoyl-[acyl-carrier- protein] reductase step.
  • The enzyme acts on very long and unsaturated fatty acids that form the meromycolic component of mycolic acids.
  • It extends FASI-derived C(20) fatty acids to form C(60) to C(90) mycolic acids.
  • The enzyme, which forms a homotetramer, is the target of the preferred antitubercular drug isoniazid.
Cross-references
BRENDA1.3.1.118
EC2PDB1.3.1.118
ExplorEnz1.3.1.118
PRIAM enzyme-specific profiles1.3.1.118
KEGG Ligand Database for Enzyme Nomenclature1.3.1.118
IUBMB Enzyme Nomenclature1.3.1.118
IntEnz1.3.1.118
MEDLINEFind literature relating to 1.3.1.118
MetaCyc1.3.1.118

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