ID   1.3.1.22
DE   3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)).
AN   3-oxo-5alpha-steroid 4-dehydrogenase.
AN   cholestenone 5alpha-reductase.
CA   a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH +
CA   H(+).
CC   -!- The enzyme catalyzes the conversion of assorted 3-oxo-Delta(4)
CC       steroids into their corresponding 5alpha form.
CC   -!- Substrates for the mammalian enzyme include testosterone,
CC       progesterone, and corticosterone.
CC   -!- Substrates for the plant enzyme are brassinosteroids such as campest-
CC       4-en-3-one and (22alpha)-hydroxy-campest-4-en-3-one. cf. EC 1.3.99.5.
CC   -!- Formerly EC 1.3.1.4 and EC 1.3.1.30.
DR   Q38944, DET2_ARATH ;  I1HTF7, DET2_BRADI ;  Q2QDF6, DET2_GOSHI ;
DR   Q5K2N1, DET2_SOLLC ;  A5PJS2, S5A1_BOVIN ;  P18405, S5A1_HUMAN ;
DR   Q28891, S5A1_MACFA ;  Q68FF9, S5A1_MOUSE ;  P24008, S5A1_RAT   ;
DR   P31213, S5A2_HUMAN ;  Q28892, S5A2_MACFA ;  Q99N99, S5A2_MOUSE ;
DR   O18765, S5A2_PIG   ;  P31214, S5A2_RAT   ;  D2HBV9, SR5A3_AILME;
DR   Q5RIU9, SR5A3_DANRE;  Q9H8P0, SR5A3_HUMAN;  C7T2J9, SR5A3_MESAU;
DR   Q9WUP4, SR5A3_MOUSE;  Q5RJM1, SR5A3_RAT  ;  Q8AVI9, SR5A3_XENLA;
DR   Q0P4J9, SR5A3_XENTR;
//