ID   1.3.1.3
DE   Delta(4)-3-oxosteroid 5beta-reductase.
AN   3-oxo-Delta(4)-steroid 5beta-reductase.
AN   5beta-reductase.
AN   androstenedione 5beta-reductase.
AN   cholestenone 5beta-reductase.
AN   cortisone 5beta-reductase.
AN   cortisone beta-reductase.
AN   cortisone Delta(4)-5beta-reductase.
AN   Delta(4)-3-ketosteroid 5beta-reductase.
AN   Delta(4)-5beta-reductase.
AN   Delta(4)-hydrogenase.
AN   steroid 5beta-reductase.
AN   testosterone 5beta-reductase.
CA   a 3-oxo-5beta-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + H(+) +
CA   NADPH.
CC   -!- The enzyme from human efficiently catalyzes the reduction of
CC       progesterone, androstenedione, 17alpha-hydroxyprogesterone and
CC       testosterone to 5beta-reduced metabolites; it can also act on
CC       aldosterone, corticosterone and cortisol, but to a lesser extent.
CC   -!- The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3-
CC       one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates.
DR   Q6PQJ9, 5BPOR_DIGLA;  P51857, AK1D1_HUMAN;  Q8VCX1, AK1D1_MOUSE;
DR   Q9TV64, AK1D1_RABIT;  P31210, AK1D1_RAT  ;  Q9STX2, VEP1_ARATH ;
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