A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.3.1.48
| Accepted Name |
|---|
| 15-oxoprostaglandin 13-reductase.
|
| Alternative Name(s) |
|---|
| 15-oxo-Delta(13)-prostaglandin reductase. |
| Prostaglandin 13-reductase. |
| Reaction catalysed |
|---|
| 11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) <=> (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H |
| Comment(s) |
|---|
- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
- The enzyme from placenta is specific for NAD(+).
|
| Cross-references |
|---|
| BRENDA | 1.3.1.48 |
| EC2PDB | 1.3.1.48 |
| ExplorEnz | 1.3.1.48 |
| PRIAM enzyme-specific profiles | 1.3.1.48 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.48 |
| IUBMB Enzyme Nomenclature | 1.3.1.48 |
| IntEnz | 1.3.1.48 |
| MEDLINE | Find literature relating to 1.3.1.48 |
| MetaCyc | 1.3.1.48 |
| UniProtKB/Swiss-Prot |
| Q3SZJ4, PTGR1_BOVIN; | Q9EQZ5, PTGR1_CAVPO; | Q14914, PTGR1_HUMAN; |
| Q91YR9, PTGR1_MOUSE; | Q29073, PTGR1_PIG; | Q28719, PTGR1_RABIT; |
| P97584, PTGR1_RAT; | Q32L99, PTGR2_BOVIN; | Q8N8N7, PTGR2_HUMAN; |
| Q8VDQ1, PTGR2_MOUSE; | Q5R806, PTGR2_PONAB; | Q5BK81, PTGR2_RAT; |
| Q24K16, PTGR3_BOVIN; | Q8N4Q0, PTGR3_HUMAN; | Q8BGC4, PTGR3_MOUSE; |
|
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