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ENZYME entry: EC 1.3.1.48

Accepted Name
15-oxoprostaglandin 13-reductase.
Alternative Name(s)
15-oxo-Delta(13)-prostaglandin reductase.
Prostaglandin 13-reductase.
Reaction catalysed
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) <=> (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
Comment(s)
  • Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
  • The enzyme from placenta is specific for NAD(+).
Cross-references
BRENDA1.3.1.48
EC2PDB1.3.1.48
ExplorEnz1.3.1.48
PRIAM enzyme-specific profiles1.3.1.48
KEGG Ligand Database for Enzyme Nomenclature1.3.1.48
IUBMB Enzyme Nomenclature1.3.1.48
IntEnz1.3.1.48
MEDLINEFind literature relating to 1.3.1.48
MetaCyc1.3.1.48
Rhea expert-curated reactions1.3.1.48
UniProtKB/Swiss-Prot
Q3SZJ4, PTGR1_BOVIN;  Q9EQZ5, PTGR1_CAVPO;  Q14914, PTGR1_HUMAN;  
Q91YR9, PTGR1_MOUSE;  Q29073, PTGR1_PIG;  Q28719, PTGR1_RABIT;  
P97584, PTGR1_RAT;  Q32L99, PTGR2_BOVIN;  Q8N8N7, PTGR2_HUMAN;  
Q8VDQ1, PTGR2_MOUSE;  Q5R806, PTGR2_PONAB;  Q5BK81, PTGR2_RAT;  
Q24K16, PTGR3_BOVIN;  Q8N4Q0, PTGR3_HUMAN;  Q8BGC4, PTGR3_MOUSE;  

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