ENZYME entry: EC 1.3.1.48
Accepted Name |
15-oxoprostaglandin 13-reductase.
|
Alternative Name(s) |
15-oxo-Delta(13)-prostaglandin reductase. |
prostaglandin 13-reductase. |
Reaction catalysed |
- 13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) <=> 15-oxoprostaglandin E2 + H(+) + NADPH
- 13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) <=> 15-oxoprostaglandin E2 + H(+) + NADH
|
Comment(s) |
- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.
- The enzyme from placenta is specific for NAD(+).
|
Cross-references |
BRENDA | 1.3.1.48 |
EC2PDB | 1.3.1.48 |
ExplorEnz | 1.3.1.48 |
PRIAM enzyme-specific profiles | 1.3.1.48 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.48 |
IUBMB Enzyme Nomenclature | 1.3.1.48 |
IntEnz | 1.3.1.48 |
MEDLINE | Find literature relating to 1.3.1.48 |
MetaCyc | 1.3.1.48 |
Rhea expert-curated reactions | 1.3.1.48 |
UniProtKB/Swiss-Prot |
Q3SZJ4, PTGR1_BOVIN; | Q9EQZ5, PTGR1_CAVPO; | Q14914, PTGR1_HUMAN; |
Q91YR9, PTGR1_MOUSE; | Q29073, PTGR1_PIG; | Q28719, PTGR1_RABIT; |
P97584, PTGR1_RAT; | Q32L99, PTGR2_BOVIN; | Q8N8N7, PTGR2_HUMAN; |
Q8VDQ1, PTGR2_MOUSE; | Q5R806, PTGR2_PONAB; | Q5BK81, PTGR2_RAT; |
Q24K16, PTGR3_BOVIN; | Q8N4Q0, PTGR3_HUMAN; | Q8BGC4, PTGR3_MOUSE; |
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UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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