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ENZYME entry: EC 1.3.1.51

Accepted Name
2'-hydroxydaidzein reductase.
Alternative Name(s)
2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase.
HDR.
NADPH:2'-hydroxydaidzein oxidoreductase.
Reaction catalysed
2'-hydroxy-2,3-dihydrodaidzein + NADP(+) <=> 2'-hydroxydaidzein + 2 H(+) + NADPH
Comment(s)
  • In the reverse reaction, the 2'-hydroxyisoflavone (2'-hydroxydaidzein) is reduced to an isoflavanone.
  • Also acts on 2'-hydroxyformononetin and to a small extent on 2'-hydroxygenistein.
  • Involved in the biosynthesis of the phytoalexin glyceollin.
  • The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates.
Cross-references
BRENDA1.3.1.51
EC2PDB1.3.1.51
ExplorEnz1.3.1.51
PRIAM enzyme-specific profiles1.3.1.51
KEGG Ligand Database for Enzyme Nomenclature1.3.1.51
IUBMB Enzyme Nomenclature1.3.1.51
IntEnz1.3.1.51
MEDLINEFind literature relating to 1.3.1.51
MetaCyc1.3.1.51
Rhea expert-curated reactions1.3.1.51

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