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ENZYME entry: EC 1.3.1.81

Accepted Name
(+)-pulegone reductase.
Reaction catalysed
  • (1R,4S)-menthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH
  • (2R,5R)-isomenthone + NADP(+) <=> (R)-pulegone + H(+) + NADPH
Comment(s)
  • NADH cannot replace NADPH as reductant.
  • The Delta(8,9)-double bond of (+)-cis-isopulegone and the Delta(1,2)- double bond of (+-)-piperitone are not substrates.
  • The enzyme from peppermint (Mentha x piperita) converts (+)-pulegone into both (-)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyze the reverse reaction.
Cross-references
BRENDA1.3.1.81
EC2PDB1.3.1.81
ExplorEnz1.3.1.81
PRIAM enzyme-specific profiles1.3.1.81
KEGG Ligand Database for Enzyme Nomenclature1.3.1.81
IUBMB Enzyme Nomenclature1.3.1.81
IntEnz1.3.1.81
MEDLINEFind literature relating to 1.3.1.81
MetaCyc1.3.1.81
Rhea expert-curated reactions1.3.1.81
UniProtKB/Swiss-Prot
Q6WAU0, PULR_MENPI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-