ID 1.3.1.82 DE (-)-isopiperitenone reductase. CA (2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + H(+) + NADPH. CC -!- The reaction occurs in the opposite direction to that shown above. CC -!- Participates in the menthol-biosynthesis pathway of Mentha plants. CC -!- (+)-Pulegone, (+)-cis-isopulegone and (-)-menthone are not CC substrates. CC -!- Has a preference for NADPH as the reductant, with NADH being a poor CC substitute. CC -!- Highly regioselective for the reduction of the endocyclic 1,2-double CC bond, and is stereoselective, producing only the 1R-configured CC product. DR Q6WAU1, IPIPR_MENPI; //