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ENZYME entry: EC 1.3.1.85
| Accepted Name |
|---|
| crotonyl-CoA carboxylase/reductase.
|
| Alternative Name(s) |
|---|
| CCR. |
| crotonyl-CoA reductase (carboxylating). |
| Reaction catalysed |
|---|
| (2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH |
| Comment(s) |
|---|
- The reaction is catalyzed in the reverse direction.
- This enzyme, isolated from the bacterium Rhodobacter sphaeroides,
catalyzes (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the
presence of CO2.
- When CO2 is absent, the enzyme catalyzes the reduction of (E)-but-2-
enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity
(relative to (E)-but-2-enoyl-CoA carboxylation).
|
| Cross-references |
|---|
| BRENDA | 1.3.1.85 |
| EC2PDB | 1.3.1.85 |
| ExplorEnz | 1.3.1.85 |
| PRIAM enzyme-specific profiles | 1.3.1.85 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.85 |
| IUBMB Enzyme Nomenclature | 1.3.1.85 |
| IntEnz | 1.3.1.85 |
| MEDLINE | Find literature relating to 1.3.1.85 |
| MetaCyc | 1.3.1.85 |
| Rhea expert-curated reactions | 1.3.1.85 |
| UniProtKB/Swiss-Prot |
|
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