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ENZYME

ENZYME entry: EC 1.3.1.85

Accepted Name
crotonyl-CoA carboxylase/reductase
Alternative Name(s)
CCR
crotonyl-CoA reductase (carboxylating)
Reaction catalysed
(2S)-ethylmalonyl-CoA + NADP(+) <=> (2E)-butenoyl-CoA + CO2 + NADPH
Comment(s)
  • The reaction is catalyzed in the reverse direction.
  • This enzyme, isolated from the bacterium Rhodobacter sphaeroides, catalyzes (E)-but-2-enoyl-CoA-dependent oxidation of NADPH in the presence of CO2.
  • When CO2 is absent, the enzyme catalyzes the reduction of (E)-but-2- enoyl-CoA to butanoyl-CoA, but with only 10% of maximal activity (relative to (E)-but-2-enoyl-CoA carboxylation).
Cross-references
BRENDA1.3.1.85
EC2PDB1.3.1.85
ExplorEnz1.3.1.85
PRIAM enzyme-specific profiles1.3.1.85
KEGG Ligand Database for Enzyme Nomenclature1.3.1.85
IUBMB Enzyme Nomenclature1.3.1.85
IntEnz1.3.1.85
MEDLINEFind literature relating to 1.3.1.85
MetaCyc1.3.1.85
Rhea expert-curated reactions1.3.1.85
UniProtKB/Swiss-Prot
Q3IZ91, CCCR_CERS4

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