ID 1.3.4.1 DE fumarate reductase (CoM/CoB). AN thiol:fumarate reductase. CA coenzyme B + coenzyme M + fumarate = coenzyme M-coenzyme B CA heterodisulfide + succinate. CC -!- The enzyme, isolated from the archaeon Methanobacterium CC thermoautotrophicum, is very oxygen sensitive. CC -!- It cannot use reduced flavins, reduced coenzyme F420, or NAD(P)H as CC an electron donor. CC -!- Distinct from EC 1.3.1.6, EC 1.3.5.1 and EC 1.3.5.4. CC -!- Formerly EC 1.3.98.2. DR D9PU00, TFRA_METTM ; D9PUX5, TFRB_METTM ; //