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ENZYME entry: EC 1.3.7.4

Accepted Name
phytochromobilin:ferredoxin oxidoreductase.
Alternative Name(s)
PFB synthase.
phytochromobilin synthase.
PPhiB synthase.
Reaction catalysed
(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] <=> biliverdin IXalpha + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • Catalyzes the two-electron reduction of biliverdin IXalpha.
  • Can use [2Fe-2S] ferredoxins from a number of sources as acceptor but not the [4Fe-4S] ferredoxin from Clostridium pasteurianum.
  • The isomerization of (3Z)-phytochromobilin to (3E)-phytochromobilin is thought to occur prior to covalent attachment to apophytochrome in the plant cell cytoplasm.
  • Flavodoxins can be used instead of ferredoxin.
Cross-references
BRENDA1.3.7.4
EC2PDB1.3.7.4
ExplorEnz1.3.7.4
PRIAM enzyme-specific profiles1.3.7.4
KEGG Ligand Database for Enzyme Nomenclature1.3.7.4
IUBMB Enzyme Nomenclature1.3.7.4
IntEnz1.3.7.4
MEDLINEFind literature relating to 1.3.7.4
MetaCyc1.3.7.4
Rhea expert-curated reactions1.3.7.4
UniProtKB/Swiss-Prot
Q9SR43, PFBS_ARATH

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