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ENZYME

ENZYME entry: EC 1.3.8.3

PURL: https://purl.expasy.org/enzyme/EC/1.3.8.3
Accepted Name
(R)-benzylsuccinyl-CoA dehydrogenase
Reaction catalysed
(R)-2-benzylsuccinyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (E)-2-benzylidenesuccinyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • Contains a tightly-bound FAD cofactor.
  • Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)- benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA.
  • Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica.
  • Ferricenium ion is an effective artificial electron acceptor.
  • Formerly EC 1.3.99.21.
Cross-references
BRENDA1.3.8.3
EC2PDB1.3.8.3
ExplorEnz1.3.8.3
KEGG Ligand Database for Enzyme Nomenclature1.3.8.3
IUBMB Enzyme Nomenclature1.3.8.3
MEDLINEFind literature relating to 1.3.8.3
MetaCyc1.3.8.3
Rhea expert-curated reactions1.3.8.3
UniProtKB/Swiss-Prot
Q9KJE8, BBSG_THAAR

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