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ENZYME

ENZYME entry: EC 1.3.8.5

Accepted Name
short-chain 2-methylacyl-CoA dehydrogenase
Alternative Name(s)
2-methylacyl-CoA dehydrogenase
2-methyl branched chain acyl-CoA dehydrogenase
2-methyl-branched-chain-enoyl-CoA reductase
branched-chain acyl-CoA dehydrogenase
Reaction catalysed
2-methylbutanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] <=> (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]
Comment(s)
  • The mammalian enzyme catalyzes an oxidative reaction as a step in the mitochondrial beta-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation.
  • The enzyme from the parasitic helminth Ascaris suum catalyzes a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA.
  • Formerly EC 1.3.1.52 and EC 1.3.99.12.
Cross-references
BRENDA1.3.8.5
EC2PDB1.3.8.5
ExplorEnz1.3.8.5
PRIAM enzyme-specific profiles1.3.8.5
KEGG Ligand Database for Enzyme Nomenclature1.3.8.5
IUBMB Enzyme Nomenclature1.3.8.5
IntEnz1.3.8.5
MEDLINEFind literature relating to 1.3.8.5
MetaCyc1.3.8.5
Rhea expert-curated reactions1.3.8.5
UniProtKB/Swiss-Prot
Q0NXR6, ACAD8_BOVINQ9UKU7, ACAD8_HUMANQ9D7B6, ACAD8_MOUSE
Q5EAD4, ACDSB_BOVINQ54RR5, ACDSB_DICDIP45954, ACDSB_HUMAN
Q9DBL1, ACDSB_MOUSEQ5RF40, ACDSB_PONABP70584, ACDSB_RAT
Q9FS88, MBCD_SOLTU

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