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ENZYME entry: EC 1.3.8.5

Accepted Name
Short-chain 2-methylacyl-CoA dehydrogenase.
Alternative Name(s)
2-methyl branched chain acyl-CoA dehydrogenase.
2-methyl-branched-chain-enoyl-CoA reductase.
2-methylacyl-CoA dehydrogenase.
Branched-chain acyl-CoA dehydrogenase.
Reaction catalysed
2-methylbutanoyl-CoA + electron-transfer flavoprotein <=> (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H(+)
Cofactor(s)
FAD.
Comment(s)
  • The mammalian enzyme catalyzes an oxidative reaction as a step in the mitochondrial beta-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation.
  • The enzyme from the parasitic helminth Ascaris suum catalyzes a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA.
  • Formerly EC 1.3.1.52 and EC 1.3.99.12.
Cross-references
BRENDA1.3.8.5
EC2PDB1.3.8.5
ExplorEnz1.3.8.5
PRIAM enzyme-specific profiles1.3.8.5
KEGG Ligand Database for Enzyme Nomenclature1.3.8.5
IUBMB Enzyme Nomenclature1.3.8.5
IntEnz1.3.8.5
MEDLINEFind literature relating to 1.3.8.5
MetaCyc1.3.8.5
Rhea expert-curated reactions1.3.8.5
UniProtKB/Swiss-Prot
Q5EAD4, ACDSB_BOVIN;  Q54RR5, ACDSB_DICDI;  P45954, ACDSB_HUMAN;  
Q9DBL1, ACDSB_MOUSE;  Q5RF40, ACDSB_PONAB;  P70584, ACDSB_RAT;  
Q9FS88, MBCD_SOLTU;  

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