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ENZYME entry: EC 1.3.98.4
Accepted Name |
5a,11a-dehydrotetracycline reductase.
|
Alternative Name(s) |
12-dehydrotetracycline dehydrogenase. |
12-dehydrotetracycline reductase. |
dehydrooxytetracycline dehydrogenase. |
Reaction catalysed |
H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) |
Comment(s) |
The enzyme, characterized from the bacteria Streptomyces aureofaciens
and Streptomyces rimosus, catalyzes the last step in the biosynthesis
of the tetracycline antibiotics tetracycline and oxytetracycline.
|
Cross-references |
BRENDA | 1.3.98.4 |
EC2PDB | 1.3.98.4 |
ExplorEnz | 1.3.98.4 |
PRIAM enzyme-specific profiles | 1.3.98.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.98.4 |
IUBMB Enzyme Nomenclature | 1.3.98.4 |
IntEnz | 1.3.98.4 |
MEDLINE | Find literature relating to 1.3.98.4 |
MetaCyc | 1.3.98.4 |
Rhea expert-curated reactions | 1.3.98.4 |
UniProtKB/Swiss-Prot |
|
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