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ENZYME entry: EC 1.3.98.4
| Accepted Name |
|---|
| 5a,11a-dehydrotetracycline reductase.
|
| Alternative Name(s) |
|---|
| 12-dehydrotetracycline dehydrogenase. |
| 12-dehydrotetracycline reductase. |
| dehydrooxytetracycline dehydrogenase. |
| Reaction catalysed |
|---|
| H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) |
| Comment(s) |
|---|
| The enzyme, characterized from the bacteria Streptomyces aureofaciens
and Streptomyces rimosus, catalyzes the last step in the biosynthesis
of the tetracycline antibiotics tetracycline and oxytetracycline.
|
| Cross-references |
|---|
| BRENDA | 1.3.98.4 |
| EC2PDB | 1.3.98.4 |
| ExplorEnz | 1.3.98.4 |
| PRIAM enzyme-specific profiles | 1.3.98.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.98.4 |
| IUBMB Enzyme Nomenclature | 1.3.98.4 |
| IntEnz | 1.3.98.4 |
| MEDLINE | Find literature relating to 1.3.98.4 |
| MetaCyc | 1.3.98.4 |
| Rhea expert-curated reactions | 1.3.98.4 |
| UniProtKB/Swiss-Prot |
|
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