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ENZYME entry: EC 1.3.98.4

Accepted Name
5a,11a-dehydrotetracycline reductase.
Alternative Name(s)
12-dehydrotetracycline dehydrogenase.
12-dehydrotetracycline reductase.
dehydrooxytetracycline dehydrogenase.
Reaction catalysed
H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline <=> 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
Comment(s)
The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyzes the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.
Cross-references
BRENDA1.3.98.4
EC2PDB1.3.98.4
ExplorEnz1.3.98.4
PRIAM enzyme-specific profiles1.3.98.4
KEGG Ligand Database for Enzyme Nomenclature1.3.98.4
IUBMB Enzyme Nomenclature1.3.98.4
IntEnz1.3.98.4
MEDLINEFind literature relating to 1.3.98.4
MetaCyc1.3.98.4
Rhea expert-curated reactions1.3.98.4
UniProtKB/Swiss-Prot
L8EYU3, OXYR_STRR1

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