ENZYME entry: EC 1.3.98.4
| Accepted Name | ||
|---|---|---|
| 5a,11a-dehydrotetracycline reductase | ||
| Alternative Name(s) | ||
| 12-dehydrotetracycline dehydrogenase | ||
| 12-dehydrotetracycline reductase | ||
| dehydrooxytetracycline dehydrogenase | ||
| Reaction catalysed | ||
| H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) + tetracycline = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n) | ||
| Comment(s) | ||
| The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyzes the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline. | ||
| Cross-references | ||
| BRENDA | 1.3.98.4 | |
| EC2PDB | 1.3.98.4 | |
| ExplorEnz | 1.3.98.4 | |
| PRIAM enzyme-specific profiles | 1.3.98.4 | |
| KEGG Ligand Database for Enzyme Nomenclature | 1.3.98.4 | |
| IUBMB Enzyme Nomenclature | 1.3.98.4 | |
| IntEnz | 1.3.98.4 | |
| MEDLINE | Find literature relating to 1.3.98.4 | |
| MetaCyc | 1.3.98.4 | |
| Rhea expert-curated reactions | 1.3.98.4 | |
| UniProtKB/Swiss-Prot |
| |
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