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ENZYME entry: EC 1.3.98.5

Accepted Name
hydrogen peroxide-dependent heme synthase.
Alternative Name(s)
coproheme III oxidative decarboxylase.
Reaction catalysed
Fe-coproporphyrin III + 2 H(+) + 2 H2O2 <=> 2 CO2 + 4 H2O + heme b
Comment(s)
  • The enzyme participates in a heme biosynthesis pathway found in Gram- positive bacteria.
  • The initial decarboxylation step is fast and yields the three- propanoate harderoheme isomer III.
  • The second decarboxylation is much slower, cf. EC 1.3.98.6.
Cross-references
BRENDA1.3.98.5
EC2PDB1.3.98.5
ExplorEnz1.3.98.5
PRIAM enzyme-specific profiles1.3.98.5
KEGG Ligand Database for Enzyme Nomenclature1.3.98.5
IUBMB Enzyme Nomenclature1.3.98.5
IntEnz1.3.98.5
MEDLINEFind literature relating to 1.3.98.5
MetaCyc1.3.98.5
Rhea expert-curated reactions1.3.98.5
UniProtKB/Swiss-Prot
Q5WB17, CHDC_ALKCK;  C3P2E9, CHDC_BACAA;  C3LFR7, CHDC_BACAC;  
A0RLH0, CHDC_BACAH;  Q81JR3, CHDC_BACAN;  B7JHL3, CHDC_BACC0;  
Q72X61, CHDC_BACC1;  B7IRR8, CHDC_BACC2;  C1EQ58, CHDC_BACC3;  
B7HG50, CHDC_BACC4;  B7HYE9, CHDC_BACC7;  A7GVD5, CHDC_BACCN;  
B9IS21, CHDC_BACCQ;  Q814N7, CHDC_BACCR;  Q630L2, CHDC_BACCZ;  
Q6HAP7, CHDC_BACHK;  Q65DQ3, CHDC_BACLD;  A9VSI0, CHDC_BACMK;  
P39645, CHDC_BACSU;  A7Z9Y9, CHDC_BACVZ;  Q5KUD5, CHDC_GEOKA;  
A0A0K2H9D8, CHDC_GEOS3;  C5D9S7, CHDC_GEOSW;  A4ITP5, CHDC_GEOTN;  
Q9K6A4, CHDC_HALH5;  Q929Q6, CHDC_LISIN;  C1KX66, CHDC_LISMC;  
Q71XQ0, CHDC_LISMF;  B8DH02, CHDC_LISMH;  Q8Y5F1, CHDC_LISMO;  
A0AKL8, CHDC_LISW6;  A0QW25, CHDC_MYCS2;  P9WL44, CHDC_MYCTO;  
P9WL45, CHDC_MYCTU;  Q8EM37, CHDC_OCEIH;  A7WZ30, CHDC_STAA1;  
A6TZ65, CHDC_STAA2;  Q2FJ56, CHDC_STAA3;  Q2G0J1, CHDC_STAA8;  
A5IQE1, CHDC_STAA9;  Q2YS77, CHDC_STAAB;  Q5HI89, CHDC_STAAC;  
A6QEP0, CHDC_STAAE;  Q99W24, CHDC_STAAM;  Q7A759, CHDC_STAAN;  
Q6GJ81, CHDC_STAAR;  Q6GBP9, CHDC_STAAS;  A8YZT4, CHDC_STAAT;  
Q8NXW5, CHDC_STAAW;  B9DKR5, CHDC_STACT;  Q5HRF8, CHDC_STAEQ;  
Q8CTQ2, CHDC_STAES;  Q4L3R3, CHDC_STAHJ;  Q49VE0, CHDC_STAS1;  
O69830, CHDC_STRCO;  Q72HY0, CHDC_THET2;  Q5SHL6, CHDC_THET8;  
P0DTW0, CPFCB_CUTAK;  

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