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ENZYME

ENZYME entry: EC 1.3.99.27

Accepted Name
1-hydroxycarotenoid 3,4-desaturase
Alternative Name(s)
1-hydroxycarotenoid 3,4-dehydrogenase
carotenoid 3,4-dehydrogenase
hydroxyneurosporene desaturase
Reaction catalysed
A + rhodopin <=> (3E)-3,4-didehydrorhodopin + AH2
Comment(s)
  • The enzymes from Rubrivivax gelatinosus and Rhodobacter sphaeroides prefer the acyclic carotenoids (e.g. 1-hydroxy-1,2- dihydroneurosporene, 1-hydroxy-1,2-dihydrolycopene) as substrates.
  • The conversion rate for the 3,4-desaturation of the monocyclic 1'-hydroxy-1',2'-dihydro-gamma-carotene is lower.
  • The enzyme from the marine bacterium strain P99-3 shows high activity with the monocyclic carotenoid 1'-hydroxy-1',2'-dihydro-gamma- carotene.
  • The enzyme from Rhodobacter sphaeroides utilizes molecular oxygen as the electron acceptor in vitro.
  • However, oxygen is unlikely to be the natural electron acceptor under anaerobic conditions.
Cross-references
BRENDA1.3.99.27
EC2PDB1.3.99.27
ExplorEnz1.3.99.27
PRIAM enzyme-specific profiles1.3.99.27
KEGG Ligand Database for Enzyme Nomenclature1.3.99.27
IUBMB Enzyme Nomenclature1.3.99.27
IntEnz1.3.99.27
MEDLINEFind literature relating to 1.3.99.27
MetaCyc1.3.99.27
Rhea expert-curated reactions1.3.99.27
UniProtKB/Swiss-Prot
Q7WT72, CRTDH_FLAS9L7WC64, CRTDH_NONDDQ01671, CRTD_CERS4
P17059, CRTD_RHOCBQ9JPB5, CRTD_RUBGE

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