ID   1.3.99.36
DE   Cypemycin cysteine dehydrogenase (decarboxylating).
AN   Cypemycin decarboxylase.
CA   Cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys + acceptor = C(3,19),S(21)-
CA   cypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO(2) + H(2)S +
CA   reduced acceptor.
CC   -!- Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a
CC       peptide antibiotic, member of the linaridins, a class of
CC       posttranslationally modified ribosomally synthesized peptides.
CC   -!- The enzyme decarboxylates and reduces the C-terminal L-cysteine
CC       residue, producing a reactive ethenethiol group that reacts with a
CC       dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine
CC       loop that is important for the antibiotic activity of the mature
CC       peptide.
CC   -!- Formerly EC 1.3.99.n3.
DR   E5KIB9, CYPD_STRSQ ;
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