ID 1.3.99.36 DE cypemycin cysteine dehydrogenase (decarboxylating). AN cypemycin decarboxylase. CA [cypemycin](1-18)-L-Cys-L-Leu-L-Val-L-Cys + A = AH2 + C(3,19),S(21)- CA [cypemycin](1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide + CO2 + hydrogen CA sulfide. CC -!- Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a CC peptide antibiotic, member of the linaridins, a class of post- CC translationally modified ribosomally synthesized peptides. CC -!- The enzyme decarboxylates and reduces the C-terminal L-cysteine CC residue, producing a reactive ethenethiol group that reacts with a CC dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine CC loop that is important for the antibiotic activity of the mature CC peptide. CC -!- Formerly EC 1.3.99.n3. DR E5KIB9, CYPD_STRSQ ; //