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ENZYME

ENZYME entry: EC 1.4.1.12

Accepted Name
2,4-diaminopentanoate dehydrogenase
Reaction catalysed
  • (2R,4S)-2,4-diaminopentanoate + H2O + NADP(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADPH + NH4(+)
  • (2R,4S)-2,4-diaminopentanoate + H2O + NAD(+) = (2R)-2-amino-4-oxopentanoate + H(+) + NADH + NH4(+)
Comment(s)
  • Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-5- oxohexanoate, which then cyclizes non-enzymically to 1-pyrroline-2- methyl-5-carboxylate.
  • It has equal activity with NAD(+) and NADP(+) (cf. EC 1.4.1.26).
Cross-references
BRENDA1.4.1.12
EC2PDB1.4.1.12
ExplorEnz1.4.1.12
PRIAM enzyme-specific profiles1.4.1.12
KEGG Ligand Database for Enzyme Nomenclature1.4.1.12
IUBMB Enzyme Nomenclature1.4.1.12
IntEnz1.4.1.12
MEDLINEFind literature relating to 1.4.1.12
MetaCyc1.4.1.12
Rhea expert-curated reactions1.4.1.12
UniProtKB/Swiss-Prot
E3PY99, ORD_ACESD

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