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ENZYME entry: EC 1.4.1.18

Accepted Name
Lysine 6-dehydrogenase.
Alternative Name(s)
L-lysine 6-dehydrogenase.
L-lysine epsilon-dehydrogenase.
LysDH.
Reaction catalysed
L-lysine + NAD(+) <=> (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + NH(3)
Comment(s)
  • Highly specific for L-lysine as substrate, although (S)- (2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
  • While the enzyme from Agrobacterium tumefaciens can use only NAD(+), that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP(+), but more slowly.
Cross-references
PROSITEPDOC00068
BRENDA1.4.1.18
EC2PDB1.4.1.18
ExplorEnz1.4.1.18
PRIAM enzyme-specific profiles1.4.1.18
KEGG Ligand Database for Enzyme Nomenclature1.4.1.18
IUBMB Enzyme Nomenclature1.4.1.18
IntEnz1.4.1.18
MEDLINEFind literature relating to 1.4.1.18
MetaCyc1.4.1.18
Rhea expert-curated reactions1.4.1.18
UniProtKB/Swiss-Prot
Q9AJC6, LYSDH_GEOSE

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