ENZYME entry: EC 1.4.1.18
Accepted Name |
lysine 6-dehydrogenase.
|
Alternative Name(s) |
L-lysine 6-dehydrogenase. |
L-lysine epsilon-dehydrogenase. |
LysDH. |
Reaction catalysed |
L-lysine + NAD(+) <=> 2 H(+) + L-1-piperideine-6-carboxylate + NADH + NH4(+) |
Comment(s) |
- Highly specific for L-lysine as substrate, although (S)-
(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
- While the enzyme from Agrobacterium tumefaciens can use only NAD(+),
that from the thermophilic bacterium Geobacillus stearothermophilus
can also use NADP(+), but more slowly.
|
Cross-references |
BRENDA | 1.4.1.18 |
EC2PDB | 1.4.1.18 |
ExplorEnz | 1.4.1.18 |
PRIAM enzyme-specific profiles | 1.4.1.18 |
KEGG Ligand Database for Enzyme Nomenclature | 1.4.1.18 |
IUBMB Enzyme Nomenclature | 1.4.1.18 |
IntEnz | 1.4.1.18 |
MEDLINE | Find literature relating to 1.4.1.18 |
MetaCyc | 1.4.1.18 |
Rhea expert-curated reactions | 1.4.1.18 |
UniProtKB/Swiss-Prot |
|
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