ENZYME entry: EC 1.4.1.18
| Accepted Name |
|---|
| Lysine 6-dehydrogenase.
|
| Alternative Name(s) |
|---|
| L-lysine 6-dehydrogenase. |
| L-lysine epsilon-dehydrogenase. |
| LysDH. |
| Reaction catalysed |
|---|
| L-lysine + NAD(+) <=> (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + NH(3) |
| Comment(s) |
|---|
- Highly specific for L-lysine as substrate, although (S)-
(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
- While the enzyme from Agrobacterium tumefaciens can use only NAD(+),
that from the thermophilic bacterium Geobacillus stearothermophilus
can also use NADP(+), but more slowly.
|
| Cross-references |
|---|
| PROSITE | PDOC00068 |
| BRENDA | 1.4.1.18 |
| EC2PDB | 1.4.1.18 |
| ExplorEnz | 1.4.1.18 |
| PRIAM enzyme-specific profiles | 1.4.1.18 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.4.1.18 |
| IUBMB Enzyme Nomenclature | 1.4.1.18 |
| IntEnz | 1.4.1.18 |
| MEDLINE | Find literature relating to 1.4.1.18 |
| MetaCyc | 1.4.1.18 |
| UniProtKB/Swiss-Prot |
|
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