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ENZYME

ENZYME entry: EC 1.4.1.21

Accepted Name
aspartate dehydrogenase
Alternative Name(s)
NAD-dependent aspartate dehydrogenase
NADH2-dependent aspartate dehydrogenase
NADP(+)-dependent aspartate dehydrogenase
Reaction catalysed
  • H2O + L-aspartate + NADP(+) = H(+) + NADPH + NH4(+) + oxaloacetate
  • H2O + L-aspartate + NAD(+) = H(+) + NADH + NH4(+) + oxaloacetate
Comment(s)
  • The enzyme is strictly specific for L-aspartate as substrate.
  • It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyzes spontaneously to form oxaloacetate.
  • The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72 preventing its hydrolysis and enabling the de novo biosynthesis of NAD(+).
Cross-references
BRENDA1.4.1.21
EC2PDB1.4.1.21
ExplorEnz1.4.1.21
PRIAM enzyme-specific profiles1.4.1.21
KEGG Ligand Database for Enzyme Nomenclature1.4.1.21
IUBMB Enzyme Nomenclature1.4.1.21
IntEnz1.4.1.21
MEDLINEFind literature relating to 1.4.1.21
MetaCyc1.4.1.21
Rhea expert-curated reactions1.4.1.21
UniProtKB/Swiss-Prot
Q7WQR6, ASPD1_BORBRQ7W1T9, ASPD1_BORPAQ7VS76, ASPD1_BORPE
Q7WLJ8, ASPD2_BORBRQ7W850, ASPD2_BORPAQ7VX83, ASPD2_BORPE
Q7WE57, ASPD3_BORBRQ6FDH0, ASPD_ACIADB7GY04, ASPD_ACIB3
B7I8C4, ASPD_ACIB5B2HVA8, ASPD_ACIBCA3M394, ASPD_ACIBT
B0V9I9, ASPD_ACIBYO28440, ASPD_ARCFUQ89FY1, ASPD_BRADU
A6X792, ASPD_BRUA4Q397Y5, ASPD_BURL3A3MD35, ASPD_BURM7
A2RXI5, ASPD_BURM9Q62BI3, ASPD_BURMAA1UVC0, ASPD_BURMS
A3P4L6, ASPD_BURP0Q3JFK2, ASPD_BURP1A3NIZ0, ASPD_BURP6
Q63LV9, ASPD_BURPSQ2T559, ASPD_BURTAQ0K391, ASPD_CUPNH
B3R8S4, ASPD_CUPTRA6UVA8, ASPD_META3Q8TS47, ASPD_METAC
Q0W7E0, ASPD_METARQ46BD6, ASPD_METBFQ12VF1, ASPD_METBU
Q2FSK9, ASPD_METHJQ58325, ASPD_METJAQ8TZ45, ASPD_METKA
A4FY69, ASPD_METM5A9A7M3, ASPD_METM6A6VK38, ASPD_METM7
Q8PV99, ASPD_METMAQ6LZ92, ASPD_METMPO27054, ASPD_METTH
A6USM7, ASPD_METVSA9A1F7, ASPD_NITMSQ126F5, ASPD_POLSJ
Q9HYA4, ASPD_PSEAEQ1QBB6, ASPD_PSYCKQ8XRV9, ASPD_RALN1
B2UJ42, ASPD_RALPJQ5LPG8, ASPD_RUEPOA8GIW3, ASPD_SERP5
Q9X1X6, ASPD_THEMAB1LB32, ASPD_THESQ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.1.-
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