ENZYME entry: EC 1.4.1.24
Accepted Name |
3-dehydroquinate synthase II.
|
Alternative Name(s) |
DHQ synthase II. |
Reaction catalysed |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H(2)O + NAD(+) <=> 3-dehydroquinate + NH(3) + NADH |
Comment(s) |
- The enzyme, which was isolated from the archaeon Methanocaldococcus
jannaschii, plays a key role in an alternative pathway for the
biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the
canonical pathway for the biosynthesis of aromatic amino acids.
- The enzyme catalyzes a two-step reaction - an oxidative deamination,
followed by cyclization.
|
Cross-references |
BRENDA | 1.4.1.24 |
EC2PDB | 1.4.1.24 |
ExplorEnz | 1.4.1.24 |
PRIAM enzyme-specific profiles | 1.4.1.24 |
KEGG Ligand Database for Enzyme Nomenclature | 1.4.1.24 |
IUBMB Enzyme Nomenclature | 1.4.1.24 |
IntEnz | 1.4.1.24 |
MEDLINE | Find literature relating to 1.4.1.24 |
MetaCyc | 1.4.1.24 |
UniProtKB/Swiss-Prot |
O30010, DHQS_ARCFU; | A0RU27, DHQS_CENSY; | Q5V143, DHQS_HALMA; |
B0R336, DHQS_HALS3; | Q9HSB6, DHQS_HALSA; | Q18DY6, DHQS_HALWD; |
B1L5W7, DHQS_KORCO; | A6UW69, DHQS_META3; | Q8THC5, DHQS_METAC; |
Q0W131, DHQS_METAR; | A7I8L5, DHQS_METB6; | Q46DZ8, DHQS_METBF; |
Q12UJ7, DHQS_METBU; | Q2FQ51, DHQS_METHJ; | Q58646, DHQS_METJA; |
Q8TVI1, DHQS_METKA; | A2SU08, DHQS_METLZ; | A4G0J1, DHQS_METM5; |
A9A8T5, DHQS_METM6; | A6VHZ4, DHQS_METM7; | Q8PXE8, DHQS_METMA; |
A3CV31, DHQS_METMJ; | Q6M1B0, DHQS_METMP; | B8GF73, DHQS_METPE; |
A5UJ82, DHQS_METS3; | Q2NI00, DHQS_METST; | O26680, DHQS_METTH; |
A0B6K6, DHQS_METTP; | A6URJ1, DHQS_METVS; | Q3IRN3, DHQS_NATPD; |
A9A235, DHQS_NITMS; |
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