A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.4.1.24
| Accepted Name |
|---|
| 3-dehydroquinate synthase II.
|
| Alternative Name(s) |
|---|
| DHQ synthase II. |
| Reaction catalysed |
|---|
| 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H(2)O + NAD(+) <=> 3-dehydroquinate + NH(3) + NADH |
| Comment(s) |
|---|
- The enzyme, which was isolated from the archaeon Methanocaldococcus
jannaschii, plays a key role in an alternative pathway for the
biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the
canonical pathway for the biosynthesis of aromatic amino acids.
- The enzyme catalyzes a two-step reaction - an oxidative deamination,
followed by cyclization.
|
| Cross-references |
|---|
| BRENDA | 1.4.1.24 |
| EC2PDB | 1.4.1.24 |
| ExplorEnz | 1.4.1.24 |
| PRIAM enzyme-specific profiles | 1.4.1.24 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.4.1.24 |
| IUBMB Enzyme Nomenclature | 1.4.1.24 |
| IntEnz | 1.4.1.24 |
| MEDLINE | Find literature relating to 1.4.1.24 |
| MetaCyc | 1.4.1.24 |
| UniProtKB/Swiss-Prot |
| O30010, DHQS_ARCFU; | A0RU27, DHQS_CENSY; | Q5V143, DHQS_HALMA; |
| B0R336, DHQS_HALS3; | Q9HSB6, DHQS_HALSA; | Q18DY6, DHQS_HALWD; |
| B1L5W7, DHQS_KORCO; | A6UW69, DHQS_META3; | Q8THC5, DHQS_METAC; |
| Q0W131, DHQS_METAR; | A7I8L5, DHQS_METB6; | Q46DZ8, DHQS_METBF; |
| Q12UJ7, DHQS_METBU; | Q2FQ51, DHQS_METHJ; | Q58646, DHQS_METJA; |
| Q8TVI1, DHQS_METKA; | A2SU08, DHQS_METLZ; | A4G0J1, DHQS_METM5; |
| A9A8T5, DHQS_METM6; | A6VHZ4, DHQS_METM7; | Q8PXE8, DHQS_METMA; |
| A3CV31, DHQS_METMJ; | Q6M1B0, DHQS_METMP; | B8GF73, DHQS_METPE; |
| A5UJ82, DHQS_METS3; | Q2NI00, DHQS_METST; | O26680, DHQS_METTH; |
| A0B6K6, DHQS_METTP; | A6URJ1, DHQS_METVS; | Q3IRN3, DHQS_NATPD; |
| A9A235, DHQS_NITMS; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.4.1.-
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