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ENZYME

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ENZYME entry: EC 1.4.1.24

Accepted Name
3-dehydroquinate synthase II
Alternative Name(s)
DHQ synthase II
Reaction catalysed
2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + H2O + NAD(+) = 3-dehydroquinate + H(+) + NADH + NH4(+)
Comment(s)
  • The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme catalyzes a two-step reaction - an oxidative deamination, followed by cyclization.
Cross-references
BRENDA1.4.1.24
EC2PDB1.4.1.24
ExplorEnz1.4.1.24
PRIAM enzyme-specific profiles1.4.1.24
KEGG Ligand Database for Enzyme Nomenclature1.4.1.24
IUBMB Enzyme Nomenclature1.4.1.24
IntEnz1.4.1.24
MEDLINEFind literature relating to 1.4.1.24
MetaCyc1.4.1.24
Rhea expert-curated reactions1.4.1.24
UniProtKB/Swiss-Prot
O30010, DHQS_ARCFUA0RU27, DHQS_CENSYQ5V143, DHQS_HALMA
B0R336, DHQS_HALS3Q9HSB6, DHQS_HALSAQ18DY6, DHQS_HALWD
B1L5W7, DHQS_KORCOA6UW69, DHQS_META3Q8THC5, DHQS_METAC
Q0W131, DHQS_METARA7I8L5, DHQS_METB6Q46DZ8, DHQS_METBF
Q12UJ7, DHQS_METBUQ2FQ51, DHQS_METHJQ58646, DHQS_METJA
Q8TVI1, DHQS_METKAA2SU08, DHQS_METLZA4G0J1, DHQS_METM5
A9A8T5, DHQS_METM6A6VHZ4, DHQS_METM7Q8PXE8, DHQS_METMA
A3CV31, DHQS_METMJQ6M1B0, DHQS_METMPB8GF73, DHQS_METPE
A5UJ82, DHQS_METS3Q2NI00, DHQS_METSTO26680, DHQS_METTH
A0B6K6, DHQS_METTPA6URJ1, DHQS_METVSQ3IRN3, DHQS_NATPD
A9A235, DHQS_NITMS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.-.-
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