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ENZYME entry: EC 1.4.1.24

Accepted Name
3-dehydroquinate synthase II.
Alternative Name(s)
DHQ synthase II.
Reaction catalysed
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H(2)O + NAD(+) <=> 3-dehydroquinate + NH(3) + NADH
Comment(s)
  • The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme catalyzes a two-step reaction - an oxidative deamination, followed by cyclization.
Cross-references
BRENDA1.4.1.24
EC2PDB1.4.1.24
ExplorEnz1.4.1.24
PRIAM enzyme-specific profiles1.4.1.24
KEGG Ligand Database for Enzyme Nomenclature1.4.1.24
IUBMB Enzyme Nomenclature1.4.1.24
IntEnz1.4.1.24
MEDLINEFind literature relating to 1.4.1.24
MetaCyc1.4.1.24
Rhea expert-curated reactions1.4.1.24
UniProtKB/Swiss-Prot
O30010, DHQS_ARCFU;  A0RU27, DHQS_CENSY;  Q5V143, DHQS_HALMA;  
B0R336, DHQS_HALS3;  Q9HSB6, DHQS_HALSA;  Q18DY6, DHQS_HALWD;  
B1L5W7, DHQS_KORCO;  A6UW69, DHQS_META3;  Q8THC5, DHQS_METAC;  
Q0W131, DHQS_METAR;  A7I8L5, DHQS_METB6;  Q46DZ8, DHQS_METBF;  
Q12UJ7, DHQS_METBU;  Q2FQ51, DHQS_METHJ;  Q58646, DHQS_METJA;  
Q8TVI1, DHQS_METKA;  A2SU08, DHQS_METLZ;  A4G0J1, DHQS_METM5;  
A9A8T5, DHQS_METM6;  A6VHZ4, DHQS_METM7;  Q8PXE8, DHQS_METMA;  
A3CV31, DHQS_METMJ;  Q6M1B0, DHQS_METMP;  B8GF73, DHQS_METPE;  
A5UJ82, DHQS_METS3;  Q2NI00, DHQS_METST;  O26680, DHQS_METTH;  
A0B6K6, DHQS_METTP;  A6URJ1, DHQS_METVS;  Q3IRN3, DHQS_NATPD;  
A9A235, DHQS_NITMS;  

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