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ENZYME

ENZYME entry: EC 1.4.2.2

Accepted Name
nicotine dehydrogenase
Reaction catalysed
(S)-nicotine + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + 2 H(+) + N-methylmyosmine
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas putida S16, contains an FAD cofactor and belongs to the flavin-containing amine oxidase family.
  • The enzyme from this bacterium is specific for the c-type cytochrome CycN.
  • The product undergoes spontaneous hydrolysis to form pseudooxynicotine.
Cross-references
BRENDA1.4.2.2
EC2PDB1.4.2.2
ExplorEnz1.4.2.2
PRIAM enzyme-specific profiles1.4.2.2
KEGG Ligand Database for Enzyme Nomenclature1.4.2.2
IUBMB Enzyme Nomenclature1.4.2.2
IntEnz1.4.2.2
MEDLINEFind literature relating to 1.4.2.2
MetaCyc1.4.2.2
Rhea expert-curated reactions1.4.2.2
UniProtKB/Swiss-Prot
F8G0P2, NICA2_PSEP6

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