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ENZYME

ENZYME entry: EC 1.4.2.2

PURL: https://purl.expasy.org/enzyme/EC/1.4.2.2
Accepted Name
nicotine dehydrogenase
Reaction catalysed
(S)-nicotine + 2 Fe(III)-[cytochrome c] = N-methylmyosmine + 2 Fe(II)-[cytochrome c] + 2 H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas putida S16, contains an FAD cofactor and belongs to the flavin-containing amine oxidase family.
  • The enzyme from this bacterium is specific for the c-type cytochrome CycN.
  • The product undergoes spontaneous hydrolysis to form pseudooxynicotine.
Cross-references
Rhea expert-curated reactions1.4.2.2
ExplorEnz1.4.2.2
IUBMB Enzyme Nomenclature1.4.2.2
UniProtKB/Swiss-Prot
F8G0P2, NICA2_PSEP6
BRENDA1.4.2.2
MetaCyc1.4.2.2
KEGG Ligand Database for Enzyme Nomenclature1.4.2.2
EC2PDB1.4.2.2
MEDLINEFind literature relating to 1.4.2.2

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