ENZYME entry: EC 1.4.3.13
Accepted Name |
protein-lysine 6-oxidase.
|
Alternative Name(s) |
lysyl oxidase. |
Reaction catalysed |
H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) |
Comment(s) |
- Also acts on protein 5-hydroxylysine.
- Catalyzes the final known enzymic step required for collagen and
elastin cross-linking in the biosynthesis of normal mature
extracellular matrices.
- These reactions play an important role for the development,
elasticity and extensibility of connective tissue.
- Also active on free amines, such as cadaverine or benzylamine.
|
Cross-references |
BRENDA | 1.4.3.13 |
EC2PDB | 1.4.3.13 |
ExplorEnz | 1.4.3.13 |
PRIAM enzyme-specific profiles | 1.4.3.13 |
KEGG Ligand Database for Enzyme Nomenclature | 1.4.3.13 |
IUBMB Enzyme Nomenclature | 1.4.3.13 |
IntEnz | 1.4.3.13 |
MEDLINE | Find literature relating to 1.4.3.13 |
MetaCyc | 1.4.3.13 |
Rhea expert-curated reactions | 1.4.3.13 |
UniProtKB/Swiss-Prot |
F1QQC3, LOL2A_DANRE; | A1L1V4, LOL2B_DANRE; | F1RD85, LOX3A_DANRE; |
B8A4W9, LOX3B_DANRE; | A6H737, LOXL2_BOVIN; | E1C3U7, LOXL2_CHICK; |
Q9Y4K0, LOXL2_HUMAN; | P58022, LOXL2_MOUSE; | Q5RFQ6, LOXL2_PONAB; |
B5DF27, LOXL2_RAT; | Q08B63, LOXL2_XENLA; | B4F6N6, LOXL2_XENTR; |
P58215, LOXL3_HUMAN; | Q9Z175, LOXL3_MOUSE; | P33072, LYOX_BOVIN; |
Q05063, LYOX_CHICK; | P28300, LYOX_HUMAN; | P28301, LYOX_MOUSE; |
P45845, LYOX_PIG; | P16636, LYOX_RAT; |
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