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ENZYME entry: EC 1.4.3.13

Accepted Name
protein-lysine 6-oxidase.
Alternative Name(s)
lysyl oxidase.
Reaction catalysed
H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
Comment(s)
  • Also acts on protein 5-hydroxylysine.
  • Catalyzes the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices.
  • These reactions play an important role for the development, elasticity and extensibility of connective tissue.
  • Also active on free amines, such as cadaverine or benzylamine.
Cross-references
BRENDA1.4.3.13
EC2PDB1.4.3.13
ExplorEnz1.4.3.13
PRIAM enzyme-specific profiles1.4.3.13
KEGG Ligand Database for Enzyme Nomenclature1.4.3.13
IUBMB Enzyme Nomenclature1.4.3.13
IntEnz1.4.3.13
MEDLINEFind literature relating to 1.4.3.13
MetaCyc1.4.3.13
Rhea expert-curated reactions1.4.3.13
UniProtKB/Swiss-Prot
F1QQC3, LOL2A_DANRE;  A1L1V4, LOL2B_DANRE;  F1RD85, LOX3A_DANRE;  
B8A4W9, LOX3B_DANRE;  A6H737, LOXL2_BOVIN;  E1C3U7, LOXL2_CHICK;  
Q9Y4K0, LOXL2_HUMAN;  P58022, LOXL2_MOUSE;  Q5RFQ6, LOXL2_PONAB;  
B5DF27, LOXL2_RAT;  Q08B63, LOXL2_XENLA;  B4F6N6, LOXL2_XENTR;  
P58215, LOXL3_HUMAN;  Q9Z175, LOXL3_MOUSE;  P33072, LYOX_BOVIN;  
Q05063, LYOX_CHICK;  P28300, LYOX_HUMAN;  P28301, LYOX_MOUSE;  
P45845, LYOX_PIG;  P16636, LYOX_RAT;  

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