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ENZYME

ENZYME entry: EC 1.4.3.13

Accepted Name
protein-lysine 6-oxidase
Alternative Name(s)
lysyl oxidase
Reaction catalysed
H2O + L-lysyl-[protein] + O2 <=> (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
Comment(s)
  • Also acts on protein 5-hydroxylysine.
  • Catalyzes the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices.
  • These reactions play an important role for the development, elasticity and extensibility of connective tissue.
  • Also active on free amines, such as cadaverine or benzylamine.
Cross-references
BRENDA1.4.3.13
EC2PDB1.4.3.13
ExplorEnz1.4.3.13
PRIAM enzyme-specific profiles1.4.3.13
KEGG Ligand Database for Enzyme Nomenclature1.4.3.13
IUBMB Enzyme Nomenclature1.4.3.13
IntEnz1.4.3.13
MEDLINEFind literature relating to 1.4.3.13
MetaCyc1.4.3.13
Rhea expert-curated reactions1.4.3.13
UniProtKB/Swiss-Prot
F1QQC3, LOL2A_DANREA1L1V4, LOL2B_DANREF1RD85, LOX3A_DANRE
B8A4W9, LOX3B_DANREA6H737, LOXL2_BOVINE1C3U7, LOXL2_CHICK
Q9Y4K0, LOXL2_HUMANP58022, LOXL2_MOUSEQ5RFQ6, LOXL2_PONAB
B5DF27, LOXL2_RATQ08B63, LOXL2_XENLAB4F6N6, LOXL2_XENTR
P58215, LOXL3_HUMANQ9Z175, LOXL3_MOUSEP33072, LYOX_BOVIN
Q05063, LYOX_CHICKP28300, LYOX_HUMANP28301, LYOX_MOUSE
P45845, LYOX_PIGP16636, LYOX_RAT

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