Expasy logo

ENZYME

ENZYME entry: EC 1.4.3.13

PURL: https://purl.expasy.org/enzyme/EC/1.4.3.13
Accepted Name
protein-lysine 6-oxidase
Alternative Name(s)
lysyl oxidase
Reaction catalysed
L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)
Comment(s)
  • Also acts on protein 5-hydroxylysine.
  • Catalyzes the final known enzymic step required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices.
  • These reactions play an important role for the development, elasticity and extensibility of connective tissue.
  • Also active on free amines, such as cadaverine or benzylamine.
Cross-references
BRENDA1.4.3.13
EC2PDB1.4.3.13
ExplorEnz1.4.3.13
KEGG Ligand Database for Enzyme Nomenclature1.4.3.13
IUBMB Enzyme Nomenclature1.4.3.13
MEDLINEFind literature relating to 1.4.3.13
MetaCyc1.4.3.13
Rhea expert-curated reactions1.4.3.13
UniProtKB/Swiss-Prot
F1QQC3, LOL2A_DANREA1L1V4, LOL2B_DANREF1RD85, LOX3A_DANRE
B8A4W9, LOX3B_DANREQ95L39, LOXL1_BOVINQ08397, LOXL1_HUMAN
P97873, LOXL1_MOUSEA6H737, LOXL2_BOVINE1C3U7, LOXL2_CHICK
Q9Y4K0, LOXL2_HUMANP58022, LOXL2_MOUSEQ5RFQ6, LOXL2_PONAB
B5DF27, LOXL2_RATQ08B63, LOXL2_XENLAB4F6N6, LOXL2_XENTR
P58215, LOXL3_HUMANQ9Z175, LOXL3_MOUSEQ8MJ24, LOXL4_BOVIN
Q96JB6, LOXL4_HUMANQ924C6, LOXL4_MOUSEP33072, LYOX_BOVIN
Q05063, LYOX_CHICKP28300, LYOX_HUMANP28301, LYOX_MOUSE
P45845, LYOX_PIGP16636, LYOX_RAT

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-