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ENZYME entry: EC 1.4.3.16

Accepted Name
L-aspartate oxidase.
Alternative Name(s)
LASPO.
Reaction catalysed
L-aspartate + O(2) <=> iminosuccinate + H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • L-aspartate oxidase catalyzes the first step in the de novo biosynthesis of NAD(+) in some bacteria.
  • O(2) can be replaced by fumarate as electron acceptor, yielding succinate.
  • The ability of the enzyme to use both O(2) and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions.
  • Iminosuccinate can either be hydrolyzed to form oxaloacetate and NH(3) or can be used by EC 2.5.1.72 in the production of quinolinate.
Cross-references
BRENDA1.4.3.16
EC2PDB1.4.3.16
ExplorEnz1.4.3.16
PRIAM enzyme-specific profiles1.4.3.16
KEGG Ligand Database for Enzyme Nomenclature1.4.3.16
IUBMB Enzyme Nomenclature1.4.3.16
IntEnz1.4.3.16
MEDLINEFind literature relating to 1.4.3.16
MetaCyc1.4.3.16
Rhea expert-curated reactions1.4.3.16
UniProtKB/Swiss-Prot
Q8XWM7, NADB1_RALSO;  Q8XQG4, NADB2_RALSO;  Q8U8J4, NADB_AGRFC;  
O66973, NADB_AQUAE;  Q94AY1, NADB_ARATH;  Q9KDJ5, NADB_BACHD;  
P38032, NADB_BACSU;  Q9A4C3, NADB_CAUVC;  Q97K95, NADB_CLOAB;  
Q8XNE2, NADB_CLOPE;  Q8XA23, NADB_ECO57;  P10902, NADB_ECOLI;  
Q9HNZ0, NADB_HALSA;  Q929Z2, NADB_LISIN;  Q8Y5N4, NADB_LISMO;  
P65500, NADB_MYCBO;  Q49617, NADB_MYCLE;  P9WJJ8, NADB_MYCTO;  
P9WJJ9, NADB_MYCTU;  Q9JSX4, NADB_NEIMA;  Q9K107, NADB_NEIMB;  
Q8YXJ6, NADB_NOSS1;  Q6Z836, NADB_ORYSJ;  Q51363, NADB_PSEAE;  
Q9V2R0, NADB_PYRAB;  Q8TZL4, NADB_PYRFU;  O57765, NADB_PYRHO;  
Q98AV8, NADB_RHILO;  Q92R32, NADB_RHIME;  Q59767, NADB_RHORU;  
Q97ZC5, NADB_SACS2;  Q8Z4K0, NADB_SALTI;  Q8ZMX9, NADB_SALTY;  
Q9X8N8, NADB_STRCO;  Q972D2, NADB_SULTO;  P74562, NADB_SYNY3;  
Q9KPA4, NADB_VIBCH;  Q9PC57, NADB_XYLFA;  Q87D19, NADB_XYLFT;  
Q8ZD80, NADB_YERPE;  

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