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ENZYME entry: EC 1.4.3.16

Accepted Name
L-aspartate oxidase
Alternative Name(s)
LASPO
Reaction catalysed
L-aspartate + O2 <=> H2O2 + iminosuccinate
Comment(s)
  • L-Aspartate oxidase catalyzes the first step in the de novo biosynthesis of NAD(+) in some bacteria.
  • O2 can be replaced by fumarate as electron acceptor, yielding succinate.
  • The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions.
  • Iminosuccinate can either be hydrolyzed to form oxaloacetate and NH3 or can be used by EC 2.5.1.72 in the production of quinolinate.
Cross-references
BRENDA1.4.3.16
EC2PDB1.4.3.16
ExplorEnz1.4.3.16
PRIAM enzyme-specific profiles1.4.3.16
KEGG Ligand Database for Enzyme Nomenclature1.4.3.16
IUBMB Enzyme Nomenclature1.4.3.16
IntEnz1.4.3.16
MEDLINEFind literature relating to 1.4.3.16
MetaCyc1.4.3.16
Rhea expert-curated reactions1.4.3.16
UniProtKB/Swiss-Prot
A0A1S3YEG8, AO2A_TOBACA0A1S4BJT3, AO2B_TOBACQ8XWM7, NADB1_RALN1
Q8XQG4, NADB2_RALN1Q6F9B6, NADB_ACIADQ8U8J4, NADB_AGRFC
O66973, NADB_AQUAEQ94AY1, NADB_ARATHP38032, NADB_BACSU
Q9A4C3, NADB_CAUVCQ97K95, NADB_CLOABQ8XNE2, NADB_CLOPE
Q8XA23, NADB_ECO57P10902, NADB_ECOLIQ9KDJ5, NADB_HALH5
Q9HNZ0, NADB_HALSAQ929Z2, NADB_LISINQ8Y5N4, NADB_LISMO
P65500, NADB_MYCBOQ49617, NADB_MYCLEP9WJJ8, NADB_MYCTO
P9WJJ9, NADB_MYCTUQ9JSX4, NADB_NEIMAQ9K107, NADB_NEIMB
Q8YXJ6, NADB_NOSS1Q6Z836, NADB_ORYSJQ51363, NADB_PSEAE
Q9V2R0, NADB_PYRABQ8TZL4, NADB_PYRFUO57765, NADB_PYRHO
Q98AV8, NADB_RHILOQ92R32, NADB_RHIMEQ59767, NADB_RHORU
Q97ZC5, NADB_SACS2Q8Z4K0, NADB_SALTIQ8ZMX9, NADB_SALTY
Q9X8N8, NADB_STRCOQ972D2, NADB_SULTOP74562, NADB_SYNY3
Q9KPA4, NADB_VIBCHQ9PC57, NADB_XYLFAQ87D19, NADB_XYLFT
Q8ZD80, NADB_YERPE

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