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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.4.3.23

Accepted Name
7-chloro-L-tryptophan oxidase.
Reaction catalysed
7-chloro-L-tryptophan + O(2) <=> 2-imino-3-(7-chloroindol-3-yl)propanoate + H(2)O(2)
Comment(s)
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • During catalysis, the bound FAD is reoxidized at the expense of molecular oxygen, producing one molecule of hydrogen peroxide.
  • The enzyme shows significant preference for 7-chloro-L-tryptophan over L-tryptophan.
Cross-references
BRENDA1.4.3.23
EC2PDB1.4.3.23
ExplorEnz1.4.3.23
PRIAM enzyme-specific profiles1.4.3.23
KEGG Ligand Database for Enzyme Nomenclature1.4.3.23
IUBMB Enzyme Nomenclature1.4.3.23
IntEnz1.4.3.23
MEDLINEFind literature relating to 1.4.3.23
MetaCyc1.4.3.23
UniProtKB/Swiss-Prot
Q8KHS0, REBO_NOCAE;  Q9S3V1, VIOA_CHRVO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-