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ENZYME entry: EC 1.5.1.2

Accepted Name
pyrroline-5-carboxylate reductase.
Alternative Name(s)
P5CR.
Reaction catalysed
  • L-proline + NAD(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADH
  • L-proline + NADP(+) <=> 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
Comment(s)
Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.
Cross-references
BRENDA1.5.1.2
EC2PDB1.5.1.2
ExplorEnz1.5.1.2
PRIAM enzyme-specific profiles1.5.1.2
KEGG Ligand Database for Enzyme Nomenclature1.5.1.2
IUBMB Enzyme Nomenclature1.5.1.2
IntEnz1.5.1.2
MEDLINEFind literature relating to 1.5.1.2
MetaCyc1.5.1.2
Rhea expert-curated reactions1.5.1.2
UniProtKB/Swiss-Prot
P54904, P5CR1_ARATH;  E0TY11, P5CR1_BACSH;  P0CI77, P5CR1_BACSU;  
Q58DT4, P5CR1_BOVIN;  Q54IL7, P5CR1_DICDI;  P32322, P5CR1_HUMAN;  
Q922W5, P5CR1_MOUSE;  Q5R9X6, P5CR1_PONAB;  P54552, P5CR2_BACSU;  
Q17QJ7, P5CR2_BOVIN;  Q55E34, P5CR2_DICDI;  Q96C36, P5CR2_HUMAN;  
Q4R6W7, P5CR2_MACFA;  Q922Q4, P5CR2_MOUSE;  Q5RAQ3, P5CR2_PONAB;  
Q6AY23, P5CR2_RAT;  Q00777, P5CR3_BACSU;  Q58D08, P5CR3_BOVIN;  
Q5SPD7, P5CR3_DANRE;  Q53H96, P5CR3_HUMAN;  Q4R531, P5CR3_MACFA;  
Q9DCC4, P5CR3_MOUSE;  Q5PQJ6, P5CR3_RAT;  A1L2Q8, P5CR3_XENLA;  
O04016, P5CR_ACTCC;  O66553, P5CR_AQUAE;  Q20848, P5CR_CAEEL;  
P0C1E4, P5CR_CORGL;  P0C1E5, P5CR_CORML;  P0A9L8, P5CR_ECOLI;  
P43869, P5CR_HAEIN;  Q9ZK56, P5CR_HELPJ;  O25773, P5CR_HELPY;  
Q6CR99, P5CR_KLULA;  Q12740, P5CR_LOPAR;  Q9HH99, P5CR_METAC;  
P22350, P5CR_METSM;  P46725, P5CR_MYCLE;  P9WHU6, P5CR_MYCTO;  
P9WHU7, P5CR_MYCTU;  Q12641, P5CR_NEUCR;  Q9CPE8, P5CR_PASMU;  
Q04708, P5CR_PEA;  P22008, P5CR_PSEAE;  Q9P7Y7, P5CR_SCHPO;  
P0A9L9, P5CR_SHIFL;  P17817, P5CR_SOYBN;  Q5HFR9, P5CR_STAAC;  
Q99TZ0, P5CR_STAAM;  Q7A5G8, P5CR_STAAN;  Q6GGJ5, P5CR_STAAR;  
Q6G961, P5CR_STAAS;  Q7A0U1, P5CR_STAAW;  Q5HP48, P5CR_STAEQ;  
Q8CP51, P5CR_STAES;  Q4L6K3, P5CR_STAHJ;  Q49XV0, P5CR_STAS1;  
P74572, P5CR_SYNY3;  P54893, P5CR_THET2;  P27771, P5CR_TREPA;  
P52053, P5CR_VIBAL;  P32263, P5CR_YEAST;  L0E163, PHQD_PENFE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
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