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ENZYME entry: EC 1.5.1.27

Accepted Name
1,2-dehydroreticulinium reductase (NADPH).
Alternative Name(s)
1,2-dehydroreticulinium ion reductase.
Reaction catalysed
(R)-reticuline + NADP(+) <=> 1,2-dehydroreticulinium + NADPH
Comment(s)
  • Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant.
  • The enzyme does not catalyze the reverse reaction to any significant extent under physiological conditions.
Cross-references
BRENDA1.5.1.27
EC2PDB1.5.1.27
ExplorEnz1.5.1.27
PRIAM enzyme-specific profiles1.5.1.27
KEGG Ligand Database for Enzyme Nomenclature1.5.1.27
IUBMB Enzyme Nomenclature1.5.1.27
IntEnz1.5.1.27
MEDLINEFind literature relating to 1.5.1.27
MetaCyc1.5.1.27
Rhea expert-curated reactions1.5.1.27
UniProtKB/Swiss-Prot
P0DKI7, STORR_PAPSO

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