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ENZYME

ENZYME entry: EC 1.5.1.3

PURL: https://purl.expasy.org/enzyme/EC/1.5.1.3
Accepted Name
dihydrofolate reductase
Alternative Name(s)
tetrahydrofolate dehydrogenase
Reaction catalysed
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
Comment(s)
  • The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
  • Formerly EC 1.5.1.4.
Cross-references
BRENDA1.5.1.3
EC2PDB1.5.1.3
ExplorEnz1.5.1.3
KEGG Ligand Database for Enzyme Nomenclature1.5.1.3
IUBMB Enzyme Nomenclature1.5.1.3
MEDLINEFind literature relating to 1.5.1.3
MetaCyc1.5.1.3
Rhea expert-curated reactions1.5.1.3
UniProtKB/Swiss-Prot
Q05762, DRTS1_ARATHQ05763, DRTS2_ARATHQ23695, DRTS_CRIFA
P45350, DRTS_DAUCAP16126, DRTS_LEIAMP07382, DRTS_LEIMA
O81395, DRTS_MAIZEQ5UQG3, DRTS_MIMIVQ2QRX6, DRTS_ORYSJ
Q27828, DRTS_PARTEQ27713, DRTS_PLABAP20712, DRTS_PLACH
P13922, DRTS_PLAFKO02604, DRTS_PLAVIP46103, DRTS_PLAVN
P51820, DRTS_SOYBNQ07422, DRTS_TOXGOQ27783, DRTS_TRYBB
Q27793, DRTS_TRYCRQ04515, DYR10_ECOLXQ59408, DYR13_ECOLX
P78218, DYR15_ECOLXP00382, DYR1_ECOLXQ5V3R2, DYR1_HALMA
P00383, DYR21_ECOLXP00384, DYR22_ECOLXP05794, DYR23_ECOLX
Q5V600, DYR2_HALMAQ86XF0, DYR2_HUMANP12833, DYR3_SALTM
P11731, DYR5_ECOLXP95524, DYR6_PROMIP27422, DYR7_ECOLX
P0ABQ7, DYR8_ECOLXP0ABQ8, DYR8_SHISOQ59397, DYR9_ECOLX
P15093, DYRA_HALVDP13955, DYRA_STAAUQ9UWQ4, DYRB_HALVO
P28019, DYR_AEDALP11045, DYR_BACSUP00376, DYR_BOVIN
P04382, DYR_BPT4P57243, DYR_BUCAIQ8K9Z8, DYR_BUCAP
Q89AV2, DYR_BUCBPQ93341, DYR_CAEELP22906, DYR_CANAX
P00378, DYR_CHICKP31073, DYR_CITFRQ07801, DYR_CRYD1
P17719, DYR_DROMEP0ABQ5, DYR_ECOL6P0ABQ4, DYR_ECOLI
O62583, DYR_ENCCUP00380, DYR_ENTFCP43791, DYR_HAEIN
Q9U8B8, DYR_HELVIQ2HRC6, DYR_HHV8PP00374, DYR_HUMAN
P31074, DYR_KLEAEP00381, DYR_LACCAQ59487, DYR_LACLA
P04753, DYR_MESAUP00375, DYR_MOUSEP0A547, DYR_MYCBO
P47470, DYR_MYCGEQ9CBW1, DYR_MYCLEP78028, DYR_MYCPN
Q98Q32, DYR_MYCPUP9WNX0, DYR_MYCTOP9WNX1, DYR_MYCTU
P04174, DYR_NEIGOQ9JSQ9, DYR_NEIMAQ9K168, DYR_NEIMB
P00377, DYR_PIGP16184, DYR_PNECAQ920D2, DYR_RAT
G4VJD6, DYR_SCHMAP36591, DYR_SCHPOP0ABQ6, DYR_SHIFL
P09503, DYR_SHV21P27421, DYR_SHV24P22573, DYR_SHV2C
Q5HFZ7, DYR_STAACP0A016, DYR_STAAMP99079, DYR_STAAN
Q6GGY1, DYR_STAARQ6G9D5, DYR_STAASP0A017, DYR_STAAU
Q8NWQ9, DYR_STAAWP0C0P0, DYR_STAEPQ5HPB1, DYR_STAEQ
P0C0P1, DYR_STAESQ54277, DYR_STAHAQ54801, DYR_STRPN
Q60034, DYR_THEMAQ9PR30, DYR_UREPAP07807, DYR_YEAST
A8AGY5, FOLM_CITK8A7ZM66, FOLM_ECO24P0AFS4, FOLM_ECO57
A8A0E8, FOLM_ECOHSA1ABF1, FOLM_ECOK1Q0THM2, FOLM_ECOL5
Q8FHB1, FOLM_ECOL6B1IQY4, FOLM_ECOLCP0AFS3, FOLM_ECOLI
B1LET0, FOLM_ECOSMQ1RBJ2, FOLM_ECOUTA4W9Z4, FOLM_ENT38
A6T8N3, FOLM_KLEP7Q320W2, FOLM_SHIBSQ32G72, FOLM_SHIDS
Q0T4H1, FOLM_SHIF8Q83RC9, FOLM_SHIFLQ3Z1V9, FOLM_SHISS
Q6QGJ4, FRD_BPT5

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-