ID   1.5.1.53
DE   methylenetetrahydrofolate reductase (NADPH).
AN   5,10-CH2-H4folate reductase.
AN   5,10-methylenetetrahydrofolate reductase (FADH2).
AN   5,10-methylenetetrahydrofolate reductase (NADPH).
AN   N(5),10-methylenetetrahydrofolate reductase.
CA   (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-
CA   5,6,7,8-tetrahydrofolate + H(+) + NADPH.
CC   -!- A flavoprotein (FAD).
CC   -!- The enzyme from yeast and mammals catalyzes a physiologically
CC       irreversible reduction of 5,10-methylenetetrahydrofolate to
CC       5-methyltetrahydrofolate using NADPH as the electron donor.
CC   -!- It plays an important role in folate metabolism by regulating the
CC       distribution of one-carbon moieties between cellular methylation
CC       reactions and nucleic acid synthesis.
CC   -!- The enzyme contains an N-terminal catalytic domain and a C-terminal
CC       allosteric regulatory domain that binds S-adenosyl-L-methionine,
CC       which acts as an inhibitor. cf. EC 1.5.1.54, EC 1.5.1.20,
CC       and EC 1.5.7.1.
DR   O74927, MTHR2_SCHPO;  P53128, MTHR2_YEAST;  Q5I598, MTHR_BOVIN ;
DR   Q17693, MTHR_CAEEL ;  P42898, MTHR_HUMAN ;  Q60HE5, MTHR_MACFA ;
DR   Q9WU20, MTHR_MOUSE ;
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