ENZYME entry: EC 1.5.3.23
Accepted Name |
Glyphosate oxidoreductase.
|
Reaction catalysed |
2 glyphosate + O(2) <=> 2 aminomethylphosphonate + 2 glyoxylate |
Cofactor(s) |
FAD.
|
Comment(s) |
- Characterized from the bacterium Ochrobactrum sp. G-1.
- The catalytic cycle starts with a reduction of the FAD cofactor by
one molecule of glyphosate, yielding reduced FAD and a Schiff base of
aminomethylphosphonate with glyoxylate that is hydrolyzed to the
single components.
- The reduced FAD is reoxidized by oxygen, generating water and an
oxygenated flavin intermediate, which catalyzes the oxygenation of a
second molecule of glyphosate, forming the second pair of
aminomethylphosphonate and glyoxylate.
|
Cross-references |
BRENDA | 1.5.3.23 |
EC2PDB | 1.5.3.23 |
ExplorEnz | 1.5.3.23 |
PRIAM enzyme-specific profiles | 1.5.3.23 |
KEGG Ligand Database for Enzyme Nomenclature | 1.5.3.23 |
IUBMB Enzyme Nomenclature | 1.5.3.23 |
IntEnz | 1.5.3.23 |
MEDLINE | Find literature relating to 1.5.3.23 |
MetaCyc | 1.5.3.23 |
Rhea expert-curated reactions | 1.5.3.23 |
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UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
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