ENZYME entry: EC 1.5.3.23
| Accepted Name |
|---|
| Glyphosate oxidoreductase.
|
| Reaction catalysed |
|---|
| 2 glyphosate + O(2) <=> 2 aminomethylphosphonate + 2 glyoxylate |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- Characterized from the bacterium Ochrobactrum sp. G-1.
- The catalytic cycle starts with a reduction of the FAD cofactor by
one molecule of glyphosate, yielding reduced FAD and a Schiff base of
aminomethylphosphonate with glyoxylate that is hydrolyzed to the
single components.
- The reduced FAD is reoxidized by oxygen, generating water and an
oxygenated flavin intermediate, which catalyzes the oxygenation of a
second molecule of glyphosate, forming the second pair of
aminomethylphosphonate and glyoxylate.
|
| Cross-references |
|---|
| BRENDA | 1.5.3.23 |
| EC2PDB | 1.5.3.23 |
| ExplorEnz | 1.5.3.23 |
| PRIAM enzyme-specific profiles | 1.5.3.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.5.3.23 |
| IUBMB Enzyme Nomenclature | 1.5.3.23 |
| IntEnz | 1.5.3.23 |
| MEDLINE | Find literature relating to 1.5.3.23 |
| MetaCyc | 1.5.3.23 |
| Rhea expert-curated reactions | 1.5.3.23 |
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