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ENZYME

ENZYME entry: EC 1.5.3.25

Accepted Name
fructosyl amine oxidase (glucosone-forming)
Alternative Name(s)
amadoriase
Reaction catalysed
an N-(1-deoxy-D-fructos-1-yl)amine + O2 + H2O <=> D-glucosone + an amine + H2O2
Comment(s)
  • Reducing sugars such as glucose react with amino groups in proteins via the spontaeous Maillard reaction, forming an unstable product that undergoes spontaneous rearrangement to a keto amine compound.
  • These reactions are known as glycation reactions, and the stable products are known as Amadori products.
  • This enzyme, which contains an FAD cofactor, catalyzes a deglycation reaction that regenerates the amine reactant.
  • By-products are glucosone and hydrogen peroxide.
  • The enzymes have been reported from fungi and bacteria, but not from higher eukaryotes.
  • Specific enzymes differ in their substrate specificity. cf. EC 1.5.3.26.
Cross-references
BRENDA1.5.3.25
EC2PDB1.5.3.25
ExplorEnz1.5.3.25
PRIAM enzyme-specific profiles1.5.3.25
KEGG Ligand Database for Enzyme Nomenclature1.5.3.25
IUBMB Enzyme Nomenclature1.5.3.25
IntEnz1.5.3.25
MEDLINEFind literature relating to 1.5.3.25
MetaCyc1.5.3.25
Rhea expert-curated reactions1.5.3.25

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-