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ENZYME entry: EC 1.5.3.5

Accepted Name
(S)-6-hydroxynicotine oxidase.
Alternative Name(s)
6-hydroxy-L-nicotine oxidase.
L-6-hydroxynicotine oxidase.
Reaction catalysed
(S)-6-hydroxynicotine + H2O + O2 <=> 6-hydroxypseudooxynicotine + H2O2
Comment(s)
  • The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine.
  • The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6).
Cross-references
BRENDA1.5.3.5
EC2PDB1.5.3.5
ExplorEnz1.5.3.5
PRIAM enzyme-specific profiles1.5.3.5
KEGG Ligand Database for Enzyme Nomenclature1.5.3.5
IUBMB Enzyme Nomenclature1.5.3.5
IntEnz1.5.3.5
MEDLINEFind literature relating to 1.5.3.5
MetaCyc1.5.3.5
Rhea expert-curated reactions1.5.3.5
UniProtKB/Swiss-Prot
Q93NH4, HLNO_PAENI;  A0A075BSX9, HLNO_SHIS7;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.5.-.-
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