ENZYME entry: EC 1.5.4.1
Accepted Name |
Pyrimidodiazepine synthase.
|
Reaction catalysed |
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4-one + glutathione disulfide + H(2)O <=> 6-pyruvoyltetrahydropterin + 2 glutathione |
Comment(s) |
- In the reverse direction of reaction, the reduction of 6-pyruvoyl-
tetrahydropterin is accompanied by the opening of the 6-membered
pyrazine ring and the formation of the 7-membered diazepine ring.
- The pyrimidodiazepine involved is an acetyldihydro derivative.
- Involved in the formation of the eye pigment drosopterin in
Drosophila melanogaster.
|
Cross-references |
BRENDA | 1.5.4.1 |
EC2PDB | 1.5.4.1 |
ExplorEnz | 1.5.4.1 |
PRIAM enzyme-specific profiles | 1.5.4.1 |
KEGG Ligand Database for Enzyme Nomenclature | 1.5.4.1 |
IUBMB Enzyme Nomenclature | 1.5.4.1 |
IntEnz | 1.5.4.1 |
MEDLINE | Find literature relating to 1.5.4.1 |
MetaCyc | 1.5.4.1 |
Rhea expert-curated reactions | 1.5.4.1 |
UniProtKB/Swiss-Prot |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.5.4.-
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