ENZYME entry: EC 1.5.4.1
| Accepted Name |
|---|
| pyrimidodiazepine synthase.
|
| Reaction catalysed |
|---|
| 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 glutathione |
| Comment(s) |
|---|
- In the reverse direction of reaction, the reduction of 6-pyruvoyl-
tetrahydropterin is accompanied by the opening of the 6-membered
pyrazine ring and the formation of the 7-membered diazepine ring.
- The pyrimidodiazepine involved is an acetyldihydro derivative.
- Involved in the formation of the eye pigment drosopterin in
Drosophila melanogaster.
|
| Cross-references |
|---|
| BRENDA | 1.5.4.1 |
| EC2PDB | 1.5.4.1 |
| ExplorEnz | 1.5.4.1 |
| PRIAM enzyme-specific profiles | 1.5.4.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.5.4.1 |
| IUBMB Enzyme Nomenclature | 1.5.4.1 |
| IntEnz | 1.5.4.1 |
| MEDLINE | Find literature relating to 1.5.4.1 |
| MetaCyc | 1.5.4.1 |
| Rhea expert-curated reactions | 1.5.4.1 |
| UniProtKB/Swiss-Prot |
|
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