ID 1.5.8.4 DE dimethylglycine dehydrogenase. AN Me2GlyDH. CA (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + CA oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10- CA methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced CA [electron-transfer flavoprotein]. CC -!- An imine intermediate is channeled from the FAD binding site to the CC 5,6,7,8-tetrahydrofolate binding site through a 40 A tunnel. CC -!- In the absence of 5,6,7,8-tetrahydrofolate the enzyme forms CC formaldehyde. CC -!- Formerly EC 1.5.99.2. DR Q9UI17, M2GD_HUMAN ; Q9DBT9, M2GD_MOUSE ; Q63342, M2GD_RAT ; //