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ENZYME entry: EC 1.5.99.12

Accepted Name
cytokinin dehydrogenase.
Alternative Name(s)
cytokinin oxidase.
Reaction catalysed
A + H2O + N(6)-dimethylallyladenine <=> 3-methyl-2-butenal + adenine + AH2
Comment(s)
  • Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is a prenyl group.
  • Although this activity was previously thought to be catalyzed by a hydrogen-peroxide-forming oxidase, this enzyme does not require oxygen for activity and does not form hydrogen peroxide.
  • 2,6-dichloroindophenol, methylene blue, nitroblue tetrazolium, phenazine methosulfate and copper(II) in the presence of imidazole can act as acceptors.
  • This enzyme plays a part in regulating rice-grain production, with lower levels of the enzyme resulting in enhanced grain production.
Cross-references
BRENDA1.5.99.12
EC2PDB1.5.99.12
ExplorEnz1.5.99.12
PRIAM enzyme-specific profiles1.5.99.12
KEGG Ligand Database for Enzyme Nomenclature1.5.99.12
IUBMB Enzyme Nomenclature1.5.99.12
IntEnz1.5.99.12
MEDLINEFind literature relating to 1.5.99.12
MetaCyc1.5.99.12
Rhea expert-curated reactions1.5.99.12
UniProtKB/Swiss-Prot
Q5Z620, CKX10_ORYSJ;  Q6Z955, CKX11_ORYSJ;  O22213, CKX1_ARATH;  
Q9T0N8, CKX1_MAIZE;  Q0JQ12, CKX1_ORYSJ;  Q9FUJ3, CKX2_ARATH;  
Q4ADV8, CKX2_ORYSJ;  Q9LTS3, CKX3_ARATH;  Q8LNV6, CKX3_ORYSJ;  
Q9FUJ2, CKX4_ARATH;  Q5JLP4, CKX4_ORYSJ;  Q67YU0, CKX5_ARATH;  
Q5ZAY9, CKX5_ORYSJ;  Q9LY71, CKX6_ARATH;  Q6YW51, CKX6_ORYSJ;  
Q9FUJ1, CKX7_ARATH;  Q6YW50, CKX7_ORYSJ;  A2XVN3, CKX8_ORYSI;  
A3AVP1, CKX8_ORYSJ;  Q75K78, CKX9_ORYSJ;  P58763, CKX_WHEAT;  

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