ID   1.6.3.1
DE   NAD(P)H oxidase (H2O2-forming).
AN   dual oxidase.
AN   NAD(P)H oxidase.
AN   ThOX.
AN   THOX2.
AN   thyroid NADPH oxidase.
AN   thyroid oxidase.
AN   thyroid oxidase 2.
CA   (1) H(+) + NADPH + O2 = H2O2 + NADP(+).
CA   (2) H(+) + NADH + O2 = H2O2 + NAD(+).
CC   -!- When calcium is present, this transmembrane glycoprotein generates
CC       H2O2 by transfering electrons from intracellular NAD(P)H to
CC       extracellular molecular oxygen.
CC   -!- The electron bridge within the enzyme contains one molecule of FAD
CC       and probably two heme groups.
CC   -!- This flavoprotein is expressed at the apical membrane of thyrocytes,
CC       and provides H2O2 for the thyroid peroxidase-catalyzed biosynthesis
CC       of thyroid hormones.
DR   O61213, DUOX1_CAEEL;  Q9MZF4, DUOX1_CANLF;  Q9NRD9, DUOX1_HUMAN;
DR   Q8HZK3, DUOX1_PIG  ;  Q8CIY2, DUOX1_RAT  ;  Q9NRD8, DUOX2_HUMAN;
DR   Q8HZK2, DUOX2_PIG  ;  Q9ES45, DUOX2_RAT  ;  Q9VQH2, DUOX_DROME ;
DR   P49109, FMO5_CAVPO ;  P49326, FMO5_HUMAN ;  P97872, FMO5_MOUSE ;
DR   Q04799, FMO5_RABIT ;  Q8K4C0, FMO5_RAT   ;  F1MH07, MICA1_BOVIN;
DR   E7F9T0, MICA1_DANRE;  Q8TDZ2, MICA1_HUMAN;  Q8VDP3, MICA1_MOUSE;
DR   D3ZBP4, MICA1_RAT  ;  Q9NPH5, NOX4_HUMAN ;  Q9JHI8, NOX4_MOUSE ;
DR   Q5R5C5, NOX4_PONAB ;  Q924V1, NOX4_RAT   ;
//