ID 1.6.3.5 DE renalase. AN alpha-NAD(P)H oxidase/anomerase. CA (1) 1,2-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+). CA (2) 1,2-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+). CA (3) 1,6-dihydro-beta-NAD + H(+) + O2 = H2O2 + NAD(+). CA (4) 1,6-dihydro-beta-NADP + H(+) + O2 = H2O2 + NADP(+). CC -!- Renalase, previously thought to be a hormone, is a flavoprotein CC secreted into the blood by the kidney that oxidizes the 1,2-dihydro- CC and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- CC NAD(P)(+). CC -!- These isomeric forms, generated by non-specific reduction of beta- CC NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent CC inhibitors of primary metabolism dehydrogenases and pose a threat to CC normal respiration. DR Q5VYX0, RNLS_HUMAN ; A7RDN6, RNLS_MOUSE ; Q48MT7, RNLS_PSE14 ; DR Q888A4, RNLS_PSESM ; Q5U2W9, RNLS_RAT ; //