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ENZYME

ENZYME entry: EC 1.6.5.2

Accepted Name
NAD(P)H dehydrogenase (quinone)
Alternative Name(s)
azoreductase
dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone)
diaphorase
DT-diaphorase
flavoprotein NAD(P)H-quinone reductase
menadione oxidoreductase
menadione reductase
NAD(P)H:(quinone-acceptor)oxidoreductase
NAD(P)H: menadione oxidoreductase
NAD(P)H2 dehydrogenase (quinone)
NAD(P)H dehydrogenase
NAD(P)H menadione reductase
NAD(P)H-quinone dehydrogenase
NAD(P)H-quinone oxidoreductase
NADH-menadione reductase
naphthoquinone reductase
p-benzoquinone reductase
phylloquinone reductase
quinone reductase
reduced NAD(P)H dehydrogenase
reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase
viologen accepting pyridine nucleotide oxidoreductase
vitamin K reductase
vitamin-K reductase
Reaction catalysed
  • a quinone + H(+) + NADH <=> a quinol + NAD(+)
  • a quinone + H(+) + NADPH <=> a quinol + NADP(+)
Comment(s)
  • The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone.
  • The animal, but not the plant, form of the enzyme is inhibited by dicoumarol.
  • Formerly EC 1.6.99.2.
Cross-references
BRENDA1.6.5.2
EC2PDB1.6.5.2
ExplorEnz1.6.5.2
PRIAM enzyme-specific profiles1.6.5.2
KEGG Ligand Database for Enzyme Nomenclature1.6.5.2
IUBMB Enzyme Nomenclature1.6.5.2
IntEnz1.6.5.2
MEDLINEFind literature relating to 1.6.5.2
MetaCyc1.6.5.2
Rhea expert-curated reactions1.6.5.2
UniProtKB/Swiss-Prot
P74312, ARREH_SYNY3P0AGE7, CHRR_ECO57P0AGE6, CHRR_ECOLI
Q88FF8, CHRR_PSEPKQ93T20, CHRR_PSEPUP0AGE8, CHRR_SHIFL
Q9LSQ5, FQR1_ARATHQ6NQE2, FQRL1_ARATHO23207, FQRL2_ARATH
Q9LUX9, FQRL3_ARATHA8ALQ5, KEFF_CITK8A7ZHD9, KEFF_ECO24
B7UI92, KEFF_ECO27B7MAG9, KEFF_ECO45B7L4G9, KEFF_ECO55
Q8XA24, KEFF_ECO57B5YZ82, KEFF_ECO5EB7NHF0, KEFF_ECO7I
B7MNQ3, KEFF_ECO81B7M0E3, KEFF_ECO8AC4ZPX2, KEFF_ECOBW
B1XC47, KEFF_ECODHA7ZVZ8, KEFF_ECOHSA1A795, KEFF_ECOK1
Q0TLU3, KEFF_ECOL5P0A755, KEFF_ECOL6B1IRD0, KEFF_ECOLC
P0A754, KEFF_ECOLIB7N7S1, KEFF_ECOLUB6HYZ7, KEFF_ECOSE
B1LFY0, KEFF_ECOSMQ1RGF2, KEFF_ECOUTA4W6F2, KEFF_ENT38
B7LVT7, KEFF_ESCF3Q9X755, KEFF_KLEAEB5Y1Z9, KEFF_KLEP3
B5F766, KEFF_SALA4A9MQG7, KEFF_SALARQ57TH5, KEFF_SALCH
B5FI28, KEFF_SALDCB5R1S3, KEFF_SALEPB5RGB7, KEFF_SALG2
B4TII5, KEFF_SALHSB4T6L1, KEFF_SALNSC0Q4M9, KEFF_SALPC
B4TWT0, KEFF_SALSVQ8Z9K1, KEFF_SALTIQ8ZRW3, KEFF_SALTY
B2U254, KEFF_SHIB3Q326I7, KEFF_SHIBSQ32K50, KEFF_SHIDS
Q0T8E9, KEFF_SHIF8Q83SQ4, KEFF_SHIFLQ3Z5W3, KEFF_SHISS
A8AQP1, KEFG_CITK8A7ME22, KEFG_CROS8A7ZSM7, KEFG_ECO24
B7UK62, KEFG_ECO27B7MCW7, KEFG_ECO45B7L4M8, KEFG_ECO55
P0A758, KEFG_ECO57B5YTQ8, KEFG_ECO5EB7NMB9, KEFG_ECO7I
B7N1D3, KEFG_ECO81B7M1Q3, KEFG_ECO8AC4ZUK7, KEFG_ECOBW
B1X6K1, KEFG_ECODHA8A5F9, KEFG_ECOHSA1AGN7, KEFG_ECOK1
Q0TCA9, KEFG_ECOL5P0A757, KEFG_ECOL6B1IPB3, KEFG_ECOLC
P0A756, KEFG_ECOLIB7NDW0, KEFG_ECOLUB6I2R0, KEFG_ECOSE
Q1R5T1, KEFG_ECOUTA4WFE5, KEFG_ENT38B2VK48, KEFG_ERWT9
B7LS58, KEFG_ESCF3Q6CZU4, KEFG_PECASC6DG98, KEFG_PECCP
B5F8H0, KEFG_SALA4Q57J14, KEFG_SALCHB5FJN2, KEFG_SALDC
B5R2A9, KEFG_SALEPB5RGZ7, KEFG_SALG2B4TKN3, KEFG_SALHS
B4SUV8, KEFG_SALNSQ5PL20, KEFG_SALPAA9MT18, KEFG_SALPB
C0Q0D4, KEFG_SALPCB5BH04, KEFG_SALPKB4TXG0, KEFG_SALSV
P65511, KEFG_SALTIP65510, KEFG_SALTYA8GKL4, KEFG_SERP5
Q32B14, KEFG_SHIDSQ0SZW5, KEFG_SHIF8Q83PX9, KEFG_SHIFL
A1JS77, KEFG_YERE8A7FNQ1, KEFG_YERP3Q1C2S8, KEFG_YERPA
B2K5P7, KEFG_YERPBQ8ZJC5, KEFG_YERPEA9R474, KEFG_YERPG
Q1CCS6, KEFG_YERPNA4TGX4, KEFG_YERPPQ664Q4, KEFG_YERPS
B1JIU3, KEFG_YERPYP9WHH6, LPDA_MYCTOP9WHH7, LPDA_MYCTU
Q8CHK7, NQO1_CAVPOP15559, NQO1_HUMANQ64669, NQO1_MOUSE
Q5RD31, NQO1_PONABP05982, NQO1_RATQ92PU3, NQOR1_RHIME
Q930L2, NQOR2_RHIMEQ92Y27, NQOR3_RHIMEA5G020, NQOR_ACICJ
B9M9X5, NQOR_ACIETB7J4K3, NQOR_ACIF2B5EMU4, NQOR_ACIF5
B6JBZ6, NQOR_AFIC5P58795, NQOR_AGRFCB9JEB9, NQOR_AGRRK
Q0A961, NQOR_ALKEHO29904, NQOR_ARCFUQ5P5L5, NQOR_AROAE
A8HRS7, NQOR_AZOC5A1K9S9, NQOR_AZOSBC1DFX8, NQOR_AZOVD
B2IEF8, NQOR_BEII9Q89D74, NQOR_BRADUA5ECG6, NQOR_BRASB
A4Z0W6, NQOR_BRASOB2S5Q9, NQOR_BRUA1Q2YQ23, NQOR_BRUA2
A6X0U8, NQOR_BRUA4Q57D82, NQOR_BRUABA9M560, NQOR_BRUC2
C0RJ23, NQOR_BRUMBQ8YH68, NQOR_BRUMEA5VQI8, NQOR_BRUO2
B0CGJ9, NQOR_BRUSIQ8G0P0, NQOR_BRUSUB1Z3G9, NQOR_BURA4
A0KCF0, NQOR_BURCHB4EPK7, NQOR_BURCJQ0B2K2, NQOR_BURCM
Q39LI8, NQOR_BURL3A9AT43, NQOR_BURM1B1KBY1, NQOR_BURO0
Q1BIC1, NQOR_BURO1A4JT91, NQOR_BURVGB0SZC3, NQOR_CAUSK
Q9AA17, NQOR_CAUVCB8H1H5, NQOR_CAUVNQ11IN8, NQOR_CHESB
Q1QYF4, NQOR_CHRSDA8AI59, NQOR_CITK8Q1LFW3, NQOR_CUPMC
Q9RYU4, NQOR_DEIRAA7ZKA9, NQOR_ECO24B7UNY7, NQOR_ECO27
B7MIE9, NQOR_ECO45B7LFB3, NQOR_ECO55Q8X4B4, NQOR_ECO57
B5YU47, NQOR_ECO5EB7NLC1, NQOR_ECO7IB7M8Y8, NQOR_ECO8A
C4ZQD2, NQOR_ECOBWB1X9C5, NQOR_ECODHA7ZYV7, NQOR_ECOHS
A1A9Q9, NQOR_ECOK1Q0TJ63, NQOR_ECOL5P0A8G7, NQOR_ECOL6
B1IV93, NQOR_ECOLCP0A8G6, NQOR_ECOLIB7N3F9, NQOR_ECOLU
B6I980, NQOR_ECOSEB1LJ00, NQOR_ECOSMQ1RDL3, NQOR_ECOUT
A4W916, NQOR_ENT38B7LP27, NQOR_ESCF3B9M4V3, NQOR_GEODF
Q39XL1, NQOR_GEOMGQ74F05, NQOR_GEOSLA5G4G8, NQOR_GEOUR
A9HFY5, NQOR_GLUDAA1WUN2, NQOR_HALHLQ31GW8, NQOR_HYDCU
B5XXP0, NQOR_KLEP3A6W2V6, NQOR_MARMSA1U5D9, NQOR_MARN8
P58796, NQOR_METACQ46B88, NQOR_METBFB7KQ28, NQOR_METC4
A9VY95, NQOR_METEPQ8PUV4, NQOR_METMAB1ZJX9, NQOR_METPB
B1LY35, NQOR_METRJB0UFU2, NQOR_METS4B8EMJ5, NQOR_METSB
Q3J8H5, NQOR_NITOCQ3SU01, NQOR_NITWNA1BAT3, NQOR_PARDP
A7HVA3, NQOR_PARL1B2JML0, NQOR_PARP8B2T8L2, NQOR_PARPJ
Q7N5I5, NQOR_PHOLLQ9I509, NQOR_PSEAEQ1MHW6, NQOR_RHIL3
A5VA47, NQOR_RHIWRB6ITN1, NQOR_RHOCSQ2IRH1, NQOR_RHOP2
Q07TR7, NQOR_RHOP5Q6NBB9, NQOR_RHOPAQ21B81, NQOR_RHOPB
Q130C0, NQOR_RHOPSB3QFA1, NQOR_RHOPTQ2RXG7, NQOR_RHORT
B5F202, NQOR_SALA4A9MH45, NQOR_SALARB5FR47, NQOR_SALDC
B5R056, NQOR_SALEPB5R6H0, NQOR_SALG2B4TEP2, NQOR_SALHS
B4T2V2, NQOR_SALNSQ5PG91, NQOR_SALPAA9N6R4, NQOR_SALPB
C0Q886, NQOR_SALPCB5BBG6, NQOR_SALPKB4TSN0, NQOR_SALSV
Q8Z7N9, NQOR_SALTIQ8ZQ40, NQOR_SALTYA8GCS6, NQOR_SERP5
Q32HQ6, NQOR_SHIDSQ0T630, NQOR_SHIF8P0A8G8, NQOR_SHIFL
Q3Z3B7, NQOR_SHISSC3MCH2, NQOR_SINFNC4XGC2, NQOR_SOLM1
Q2LPM7, NQOR_SYNASA0LNQ8, NQOR_SYNFMC4L7R5, NQOR_TOLAT
B3E9H6, NQOR_TRIL1A7IE31, NQOR_XANP2A1JMU2, NQOR_YERE8
A7FJ02, NQOR_YERP3Q1C8L9, NQOR_YERPAB2K198, NQOR_YERPB
Q8ZF61, NQOR_YERPEA9R7R8, NQOR_YERPGQ1CHD6, NQOR_YERPN
A4TK49, NQOR_YERPPQ66BP3, NQOR_YERPSB1JNA9, NQOR_YERPY
Q9XBR5, NQOR_ZYMMOQ941Z0, NQR1_ORYSJQ941Y8, NQR2_ORYSJ
Q9LK88, NQR_ARATHQ8H9D2, NQR_SOLTUP39315, QOR2_ECOLI
Q8NJJ9, QOR_KLUMAQ9AYU0, QR2_TRIVS

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-