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ENZYME

ENZYME entry: EC 1.6.5.9

Accepted Name
NADH:ubiquinone reductase (non-electrogenic)
Alternative Name(s)
coenzyme Q reductase
electron transfer complex I
NADH2 dehydrogenase (ubiquinone)
NADH-coenzyme Q oxidoreductase
NADH-coenzyme Q reductase
NADH-CoQ oxidoreductase
NADH-CoQ reductase
NADH-Q6 oxidoreductase
NADH-ubiquinone oxidoreductase
NADH-ubiquinone reductase
ubiquinone reductase
Reaction catalysed
a quinone + H(+) + NADH <=> a quinol + NAD(+)
Comment(s)
  • A flavoprotein (FAD or FMN).
  • Occurs in mitochondria of yeast and plants, and in aerobic bacteria.
  • Has low activity with NADPH.
  • Unlike EC 7.1.1.2, this enzyme does not pump proteons of sodium ions across the membrane.
  • It is also not sensitive to rotenone.
  • Formerly EC 1.6.5.11.
Cross-references
BRENDA1.6.5.9
EC2PDB1.6.5.9
ExplorEnz1.6.5.9
PRIAM enzyme-specific profiles1.6.5.9
KEGG Ligand Database for Enzyme Nomenclature1.6.5.9
IUBMB Enzyme Nomenclature1.6.5.9
IntEnz1.6.5.9
MEDLINEFind literature relating to 1.6.5.9
MetaCyc1.6.5.9
Rhea expert-curated reactions1.6.5.9
UniProtKB/Swiss-Prot
M1BYJ7, ENDB1_SOLTUM0ZYF3, INDA1_SOLTUQ8GWA1, NDA1_ARATH
Q9ST63, NDA1_SOLTUO80874, NDA2_ARATHQ1JPL4, NDB1_ARATH
Q9ST62, NDB1_SOLTUQ94BV7, NDB2_ARATHF4JJJ3, NDB3_ARATH
Q9SKT7, NDB4_ARATHQ8GXR9, NDC1_ARATHO14121, NDH1_SCHPO
P40215, NDH1_YEASTO43090, NDH2_SCHPOF2Z699, NDH2_YARLI
Q07500, NDH2_YEASTP95200, NDHA_MYCTUP00393, NDH_ECOLI
P44856, NDH_HAEINP95160, NDH_MYCTUQ2FID4, NDH_STAA3
Q2FZV7, NDH_STAA8Q2YWP9, NDH_STAABQ5HHE4, NDH_STAAC
Q99VE0, NDH_STAAMQ7A6J4, NDH_STAANQ6GIE7, NDH_STAAR
Q6GAY5, NDH_STAASQ8NXG0, NDH_STAAWQ5HQM1, NDH_STAEQ
Q8CPV5, NDH_STAESQ4L4V6, NDH_STAHJQ49W80, NDH_STAS1
P32340, NDI1_YEASTQ9I4V0, NQRED_PSEAE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.6.-.-
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