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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.7.2.1

Accepted Name
Nitrite reductase (NO-forming).
Alternative Name(s)
cd-cytochrome nitrite reductase.
Cytochrome c-551:O(2), NO(2)(+) oxidoreductase.
Cytochrome cd.
Cytochrome cd1.
Hydroxylamine (acceptor) reductase.
Methyl viologen-nitrite reductase.
Nitrite reductase.
Nitrite reductase (cytochrome).
Nitrite reductase (cytochrome; NO-forming).
Pseudomonas cytochrome oxidase.
Reaction catalysed
Nitric oxide + H(2)O + ferricytochrome c <=> nitrite + ferrocytochrome c + 2 H(+)
Cofactor(s)
Cu cation or Fe cation; FAD.
Comment(s)
  • The reaction is catalyzed by two types of enzymes, found in the perimplasm of denitrifying bacteria.
  • One type comprises proteins containing multiple copper centers, the other a heme protein, cytochrome cd1.
  • Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin.
  • Cytochrome cd1 also has oxidase and hydroxylamine reductase activities.
  • May also catalyze the reaction of EC 1.7.99.1 since this is a well- known activity of cytochrome cd1.
  • Formerly EC 1.6.6.5, EC 1.7.99.3 and EC 1.9.3.2.
Cross-references
BRENDA1.7.2.1
EC2PDB1.7.2.1
ExplorEnz1.7.2.1
PRIAM enzyme-specific profiles1.7.2.1
KEGG Ligand Database for Enzyme Nomenclature1.7.2.1
IUBMB Enzyme Nomenclature1.7.2.1
IntEnz1.7.2.1
MEDLINEFind literature relating to 1.7.2.1
MetaCyc1.7.2.1
UniProtKB/Swiss-Prot
Q02219, ANIA_NEIGO;  Q9JTB8, ANIA_NEIMA;  Q9JYE1, ANIA_NEIMB;  
Q92Z29, NIRK_RHIME;  Q51700, NIRS_PARDP;  P72181, NIRS_PARPN;  
P24474, NIRS_PSEAE;  P24040, NIRS_PSEST;  P25006, NIR_ACHCY;  
P38501, NIR_ALCFA;  P81445, NIR_ALCXX;  Q06006, NIR_PSECL;  
Q01537, NIR_RHIGA;  Q60214, NIR_RHISU;  Q53239, NIR_RHOS5;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.7.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-