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ENZYME entry: EC 1.7.2.6

Accepted Name
hydroxylamine dehydrogenase.
Alternative Name(s)
hydroxylamine oxidase.
hydroxylamine oxidoreductase.
Reaction catalysed
4 Fe(III)-[cytochrome c] + H2O + hydroxylamine <=> 4 Fe(II)-[cytochrome c] + 5 H(+) + nitrite
Comment(s)
  • The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins with seven c-type hemes and one specialized P460-type heme per subunit.
  • The enzyme converts hydroxylamine to nitrite via an enzyme-bound nitroxyl intermediate.
  • While nitrite is the main product, the enzyme from Nitrosomonas europaea can also produce nitric oxide by catalyzing the activity of EC 1.7.2.9.
  • Formerly EC 1.7.3.4.
Cross-references
BRENDA1.7.2.6
EC2PDB1.7.2.6
ExplorEnz1.7.2.6
PRIAM enzyme-specific profiles1.7.2.6
KEGG Ligand Database for Enzyme Nomenclature1.7.2.6
IUBMB Enzyme Nomenclature1.7.2.6
IntEnz1.7.2.6
MEDLINEFind literature relating to 1.7.2.6
MetaCyc1.7.2.6
Rhea expert-curated reactions1.7.2.6
UniProtKB/Swiss-Prot
Q50925, HAO_NITEU;  P0DV45, NRHAO_KUEST;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.7.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.7.-.-
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