ID 1.8.1.12 DE trypanothione-disulfide reductase. AN N(1),N(8)-bis(glutathionyl)spermidine reductase. AN NADPH:trypanothione oxidoreductase. AN trypanothione reductase. CA trypanothione + NADP(+) = trypanothione disulfide + NADPH + H(+). CC -!- Trypanothione disulfide is the oxidized form of N(1),N(8)- CC bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid CC Crithidia fasciculata. CC -!- The activity is dependent on a redox-active cystine at the active CC center (cf. EC 1.8.1.7). CC -!- Formerly EC 1.6.4.8. DR P39040, TYTR_CRIFA ; P39050, TYTR_LEIDO ; P39051, TYTR_TRYBB ; DR P13110, TYTR_TRYCO ; P28593, TYTR_TRYCR ; //