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ENZYME entry: EC 1.8.1.16

Accepted Name
Glutathione amide reductase.
Alternative Name(s)
GAR.
Reaction catalysed
2 glutathione amide + NAD(+) <=> glutathione amide disulfide + NADH
Comment(s)
  • The enzyme restores glutathione amide disulfide, which is produced during the reduction of peroxide by EC 1.11.1.17 back to glutathione amide (it catalyzes the reaction in the opposite direction to that shown).
  • The enzyme belongs to the family of flavoprotein disulfide oxidoreductases, but unlike other members of the family, which are specific for NADPH, it prefers NADH.
Cross-references
PROSITEPDOC00073
BRENDA1.8.1.16
EC2PDB1.8.1.16
ExplorEnz1.8.1.16
PRIAM enzyme-specific profiles1.8.1.16
KEGG Ligand Database for Enzyme Nomenclature1.8.1.16
IUBMB Enzyme Nomenclature1.8.1.16
IntEnz1.8.1.16
MEDLINEFind literature relating to 1.8.1.16
MetaCyc1.8.1.16
Rhea expert-curated reactions1.8.1.16
UniProtKB/Swiss-Prot
D0VWY5, GASHR_MARGR

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