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ENZYME

ENZYME entry: EC 1.8.1.22

PURL: https://purl.expasy.org/enzyme/EC/1.8.1.22
Accepted Name
dissimilatory sulfite reductase
Alternative Name(s)
siroheme sulfite reductase
Reaction catalysed
[DsrC protein]-trisulfide + NAD(+) + 3 H2O = [DsrC protein]-dithiol + sulfite + NADH + 3 H(+)
Comment(s)
  • Contains siroheme.
  • The enzyme is essential in prokaryotic sulfur-based energy metabolism, including sulfate/sulfite reducing organisms, sulfur- oxidizing bacteria, and organosulfonate reducers.
  • The system comprises the DsrAB reductase and the DsrL protein, which form a tight complex.
  • The reaction involves the small protein DsrC, which is present in all the organisms that contain dissimilatory sulfite reductase.
  • In sulfite reducers the DsrL component transfers two electrons from NADH to the DsrAB component, which then reduces the sulfur in sulfite to an S(II) intermediate that forms (together with two cysteine residues of DsrC) a trisulfide.
  • In sulfur oxidizers the enzyme catalyzes the opposite reaction.
  • Formerly EC 1.8.99.5.
Cross-references
BRENDA1.8.1.22
EC2PDB1.8.1.22
ExplorEnz1.8.1.22
KEGG Ligand Database for Enzyme Nomenclature1.8.1.22
IUBMB Enzyme Nomenclature1.8.1.22
MEDLINEFind literature relating to 1.8.1.22
MetaCyc1.8.1.22
Rhea expert-curated reactions1.8.1.22
UniProtKB/Swiss-Prot
O33998, DSRA_ALLVDQ59109, DSRA_ARCFUQ59110, DSRB_ARCFU
P94694, DSVB_MEGG1P45575, DSVB_NITV2P45573, DSVC_NITV2

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