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ENZYME entry: EC 1.8.1.7

Accepted Name
Glutathione-disulfide reductase.
Alternative Name(s)
Glutathione reductase.
Glutathione reductase (NADPH).
Glutathione S-reductase.
GSH reductase.
GSSG reductase.
NADPH-glutathione reductase.
NADPH-GSSG reductase.
NADPH:oxidized-glutathione oxidoreductase.
Reaction catalysed
2 glutathione + NADP(+) <=> glutathione disulfide + NADPH
Cofactor(s)
FAD.
Comment(s)
  • Activity is dependent on a redox-active disulfide in each of the active centers.
  • Formerly EC 1.6.4.2.
Cross-references
PROSITEPDOC00073
BRENDA1.8.1.7
EC2PDB1.8.1.7
ExplorEnz1.8.1.7
PRIAM enzyme-specific profiles1.8.1.7
KEGG Ligand Database for Enzyme Nomenclature1.8.1.7
IUBMB Enzyme Nomenclature1.8.1.7
IntEnz1.8.1.7
MEDLINEFind literature relating to 1.8.1.7
MetaCyc1.8.1.7
Rhea expert-curated reactions1.8.1.7
UniProtKB/Swiss-Prot
P48641, GSHRC_ARATH;  O04955, GSHRC_BRARP;  P48642, GSHRC_ORYSJ;  
Q43621, GSHRC_PEA;  P42770, GSHRP_ARATH;  P27456, GSHRP_PEA;  
P48640, GSHRP_SOYBN;  Q43154, GSHRP_SPIOL;  P80461, GSHRP_TOBAC;  
Q74ZK4, GSHR_ASHGO;  P48639, GSHR_BURCE;  Q93379, GSHR_CAEEL;  
A2TIL1, GSHR_CALJA;  Q6FRV2, GSHR_CANGA;  Q6BPI1, GSHR_DEBHA;  
Q8T137, GSHR_DICDI;  P06715, GSHR_ECOLI;  P43783, GSHR_HAEIN;  
P00390, GSHR_HUMAN;  Q6HA23, GSHR_KLULA;  P47791, GSHR_MOUSE;  
Q873E8, GSHR_NEUCR;  P48638, GSHR_NOSS1;  O15770, GSHR_PLAF7;  
Q94655, GSHR_PLAFK;  P23189, GSHR_PSEAE;  P70619, GSHR_RAT;  
P78965, GSHR_SCHPO;  P11804, GSHR_SPISP;  Q60151, GSHR_STRTR;  
Q6C5H4, GSHR_YARLI;  P41921, GSHR_YEAST;  P30635, TRXR2_CAEEL;  

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