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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.8.2.2

Accepted Name
Thiosulfate dehydrogenase.
Alternative Name(s)
Tetrathionate synthase.
Reaction catalysed
2 thiosulfate + 2 ferricytochrome c <=> tetrathionate + 2 ferrocytochrome c
Comment(s)
  • The enzyme catalyzes the reversible formation of a sulfur-sulfur bond between the sulfane atoms of two thiosulfate molecules, yielding tetrathionate and releasing two electrons.
  • In many bacterial species the enzyme is a diheme c-type cytochrome.
  • In a number of organisms, including Thiomonas intermedia and Sideroxydans lithotrophicus, a second diheme cytochrome (TsdB) acts as the electron acceptor.
  • However, some organisms, such as Allochromatium vinosum, lack TsdB.
  • The electron acceptor in these organisms may be the high-potential iron-sulfur protein (HiPIP).
Cross-references
BRENDA1.8.2.2
EC2PDB1.8.2.2
ExplorEnz1.8.2.2
PRIAM enzyme-specific profiles1.8.2.2
KEGG Ligand Database for Enzyme Nomenclature1.8.2.2
IUBMB Enzyme Nomenclature1.8.2.2
IntEnz1.8.2.2
MEDLINEFind literature relating to 1.8.2.2
MetaCyc1.8.2.2
UniProtKB/Swiss-Prot
D3RVD4, TSDA_ALLVD;  A4VND8, TSDA_PSEU5;  Q4FQB7, TSDA_PSYA2;  
D5WYQ5, TSDA_THIK1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-