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ENZYME

ENZYME entry: EC 1.8.3.5

PURL: https://purl.expasy.org/enzyme/EC/1.8.3.5
Accepted Name
prenylcysteine oxidase
Alternative Name(s)
prenylcysteine lyase
Reaction catalysed
an S-polyprenyl-L-cysteine + O2 + H2O = a polyprenal + L-cysteine + H2O2
Comment(s)
  • Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine.
  • N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates.
  • May represent the final step in the degradation of prenylated proteins in mammalian tissues.
  • Formerly EC 4.4.1.18.
Cross-references
BRENDA1.8.3.5
EC2PDB1.8.3.5
ExplorEnz1.8.3.5
KEGG Ligand Database for Enzyme Nomenclature1.8.3.5
IUBMB Enzyme Nomenclature1.8.3.5
MEDLINEFind literature relating to 1.8.3.5
MetaCyc1.8.3.5
Rhea expert-curated reactions1.8.3.5
UniProtKB/Swiss-Prot
F1N2K1, PCYOX_BOVINQ9UHG3, PCYOX_HUMANQ95KC9, PCYOX_MACFA
Q9CQF9, PCYOX_MOUSEQ5R748, PCYOX_PONABQ99ML5, PCYOX_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-