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ENZYME entry: EC

Accepted Name
formylglycine-generating enzyme.
Alternative Name(s)
Calpha-formylglycine-generating enzyme 1.
sulfatase-modifying factor 1.
Reaction catalysed
2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide
  • The enzyme, which is found in both prokaryotes and eukaryotes, catalyzes a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity.
  • The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro.
  • Glutathione alo acts in vitro, but it is not known whether it is used in vivo.
PRIAM enzyme-specific profiles1.8.3.7
KEGG Ligand Database for Enzyme Nomenclature1.8.3.7
IUBMB Enzyme Nomenclature1.8.3.7
MEDLINEFind literature relating to
Rhea expert-curated reactions1.8.3.7

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