Expasy logo

ENZYME

ENZYME entry: EC 1.8.3.7

Accepted Name
formylglycine-generating enzyme
Alternative Name(s)
Calpha-formylglycine-generating enzyme 1
sulfatase-modifying factor 1
Reaction catalysed
2 a thiol + L-cysteinyl-[sulfatase] + O2 <=> 3-oxo-L-alanyl-[sulfatase] + an organic disulfide + H(+) + H2O + hydrogen sulfide
Comment(s)
  • The enzyme, which is found in both prokaryotes and eukaryotes, catalyzes a modification of a conserved L-cysteine residue in the active site of sulfatases, generating a unique 3-oxo-L-alanine residue that is essential for sulfatase activity.
  • The exact nature of the thiol involved is still not clear - dithiothreitol and cysteamine are the most efficiently used thiols in vitro.
  • Glutathione alo acts in vitro, but it is not known whether it is used in vivo.
Cross-references
BRENDA1.8.3.7
EC2PDB1.8.3.7
ExplorEnz1.8.3.7
PRIAM enzyme-specific profiles1.8.3.7
KEGG Ligand Database for Enzyme Nomenclature1.8.3.7
IUBMB Enzyme Nomenclature1.8.3.7
IntEnz1.8.3.7
MEDLINEFind literature relating to 1.8.3.7
MetaCyc1.8.3.7
Rhea expert-curated reactions1.8.3.7
UniProtKB/Swiss-Prot
I6Y8I5, FGE_MYCTUQ9F3C7, FGE_STRCOD1A7C3, FGE_THECD
Q0P5L5, SUMF1_BOVINQ8NBK3, SUMF1_HUMANQ8R0F3, SUMF1_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-